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Original Article

Nonalcoholic steatohepatitis critically rewires the ischemia/reperfusion-induced dysregulation of cardiolipins and sphingolipids in mice
Sheng Yu, Kai Wang, Qingping Li, Yiran Wei, Yiyi Li, Qifan Zhang, Pengxiang Huang, Hanbiao Liang, Hang Sun, Hongxian Peng, Xixin Huang, Cuiting Liu, Jie Zhou, Jianping Qian, Chuanjiang Li
Nonalcoholic steatohepatitis critically promotes the I/R-induced decreases of cardiolipins and increase of ceramides, which is linked to the exaggerated I/R injury in the mouse liver of nonalcoholic steatohepatitis.
Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study
Moritz Schmelzle, Felix Krenzien, Paul Dahlke, Alina Krombholz, Nora Nevermann, Linda Feldbrügge, Axel Winter, Wenzel Schöning, Christian Benzing, Johann Pratschke, Jens Neudecker
Nab-paclitaxel plus tegafur gimeracil oteracil potassium capsule (S-1) as first-line treatment for advanced biliary tract adenocarcinoma: a phase 2 clinical trial
Wen Zhang, Yongkun Sun, Zhichao Jiang, Wang Qu, Caifeng Gong, Aiping Zhou
The novel combination of nab-paclitaxel plus S-1 as first-line treatment for advanced biliary tract adenocarcinoma yieled comparable efficacy to the standard regimens in terms of ORR, PFS and OS. The favorable tolerability makes it a potential selection of non-platinum and -gemcitabine-based regimen.
Hepatocellular carcinoma and intrahepatic cholangiocarcinoma incidence between 2006 and 2015 in China: estimates based on data from 188 population-based cancer registries
Lan An, Rongshou Zheng, Siwei Zhang, Ru Chen, Shaoming Wang, Kexin Sun, Lingeng Lu, Xuehong Zhang, Hong Zhao, Hongmei Zeng, Wenqiang Wei, Jie He

Review Article

A narrative review of the current and future role of robotic surgery in liver surgery and transplantation
Michele Finotti, Francesco D’Amico, David Mulligan, Giuliano Testa
The article reviewed the role of minimally invasive surgery in the field of liver surgery and transplantation, with a particular focus on the robotic approach. Robotic surgery, especially in living donation, can be performed safely in properly selected patients by teams with high expertise.
Surgery for metastatic pancreatic neuroendocrine tumors: a narrative review
Jelani K. Williams, Jason L. Schwarz, Xavier M. Keutgen
Surgery remains the best treatment for localized PanNETs, but it also has an important role in metastatic disease. Surgical debulking of liver metastasis in selected patients with metastatic PanNETs may confer a survival benefit, improve symptoms, and allow systemic therapies to be more efficacious.


Is HPB robotic-assisted surgery an evolution or a revolution in laparoscopy?
Jun Cao, Yajin Chen
Liver metastasis of pancreatic cancer: the new choice at the crossroads
Zhe Liu, Anjiang Gou, Xingda Wu
Is there a survival benefit of a robotic approach to pancreatoduodenectomy for pancreatic cancer?
Dyre Kleive, Sheraz Yaqub, Kjetil Søreide
Management of decompensated liver cirrhosis in the surgical intensive care unit
Philipp Kasper, Tobias Goeser
Pushing the limits for the surgical treatment of intrahepatic cholangiocarcinoma
Woo Jin Choi, Gonzalo Sapisochin
Periprocedural management of hemostatic alterations in patients with cirrhosis and vascular liver disorders: a step forward of the American Association for the Study of Liver Diseases
José Ignacio Fortea, Ángela Puente, Javier Crespo, Emilio Fábrega
The French guidelines for alcohol-related liver disease—what’s new, what’s not and what’s still needed
María Hernández-Tejero, Gavin E. Arteel
Liver transplantation for unresectable colorectal liver metastases (CRLM) using extended criteria donor (ECD) grafts: proceed with caution
Silvio Nadalin
Tailoring stepwise treatment for Budd-Chiari syndrome: insights from the Asian Pacific Association for the Study of the Liver (APASL) consensus guidance
Lamia Y. Haque, Joseph K. Lim
East meets West: what opportunities arise in comparing international guidelines for management of cirrhosis?
Celyn Idami, Nadim Mahmud

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini


Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.

Original Article

The SUPER reporting guideline suggested for reporting of surgical technique
Kaiping Zhang, Yanfang Ma, Jinlin Wu, Qianling Shi, Leandro Cardoso Barchi, Marco Scarci, Rene Horsleben Petersen, Calvin S. H. Ng, Steven Hochwald, Ryuichi Waseda, Fabio Davoli, Robert Fruscio, Giovanni Battista Levi Sandri, Michel Gonzalez, Benjamin Wei, Guillaume Piessen, Jianfei Shen, Xianzhuo Zhang, Panpan Jiao, Yulong He, Nuria M. Novoa, Benedetta Bedetti, Sebastien Gilbert, Alan D. L. Sihoe, Alper Toker, Alfonso Fiorelli, Marcelo F. Jimenez, Toni Lerut, Aung Y. Oo, Grace S. Li, Xueqin Tang, Yawen Lu, Hussein Elkhayat, Tomaž Štupnik, Tanel Laisaar, Firas Abu Akar, Diego Gonzalez-Rivas, Zhanhao Su, Bin Qiu, Stephen D. Wang, Yaolong Chen, Shugeng Gao
Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation
Charlotte Maulat, Stéphanie Truant, Christian Hobeika, Louise Barbier, Astrid Herrero, Alexandre Doussot, Johan Gagnière, Édouard Girard, Hadrien Tranchart, Jean-Marc Regimbeau, David Fuks, François Cauchy, Mathieu Prodeau, Antoine Notte, Cyprien Toubert, Ephrem Salamé, Mehdi El Amrani, Sandrine Andrieu, Fabrice Muscari, Jason Shourick, Bertrand Suc

Review Article