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Original Article

Impact of living donor liver with steatosis and idiopathic portal inflammation on clinical outcomes in pediatric liver transplantation: Beijing experience
Xinyan Zhao, Yafei He, Jimin Liu, Qian Zhang, Liwei Liu, Wei Qu, Ying Liu, Zhigui Zeng, Haiming Zhang, Jidong Jia, Liying Sun, Lin Wei, Zhijun Zhu
This study provided new evidence in pediatric living donor liver allocation. Donor liver with mild portal inflammation would better not be allocated to recipients with high pediatric-end-stage-liver-disease score.
Peripancreatic vascular involvement in patients with type 1 autoimmune pancreatitis
Meizi Li, Xiaoyin Bai, Kai Xu, Xi Wu, Tao Guo, Qingwei Jiang, Qiang Wang, Shengyu Zhang, Yingyun Yang, Yunlu Feng, Aiming Yang
This study revealed the real-world condition of peripancreatic vascular involvement (PVI) in patients with type 1 autoimmune pancreatitis (AIP) and described independent predictors of PVI development in AIP patients. The follow-up showed majority of PVI lesions achieved an improvement after corticosteroid treatment.
Have we really understood when the efforts of laparoscopic liver resection are justified?—a complexity-based appraisal of the differential benefit
Francesca Ratti, Federica Cipriani, Guido Fiorentini, Marco Catena, Michele Paganelli, Luca Aldrighetti
The favorable biological scenario associated with laparoscopy allows to obtain significant benefits in the setting of complex procedures, constituting the prerequisite for adequate surgical outcome. The effort should be to maximize the laparoscopic approach in high complexity procedures by implementing surgical technique and perioperative management.
Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma
Takehiro Noji, Satoko Uemura, Jimme K. Wiggers, Kimitaka Tanaka, Yoshitsugu Nakanishi, Toshimichi Asano, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Pim B. Olthof, William R. Jarnagin, Thomas M. van Gulik, Satoshi Hirano
We validate postoperative liver failure (PHLFS) and mortality risk scores (POMRS) after liver resection for perihilar cholangiocarcinoma, which was established by Western cohort, by Eastern cohort. This external validation study showed that for PHLFS the threshold for discrimination, but the POMRS were not applicable.
Impact of pathological response after preoperative transcatheter arterial chemoembolization (TACE) on incidences of microvascular invasion and early tumor recurrence in hepatocellular carcinoma: a multicenter propensity score matching analysis
Yun Yang, Zheng Dang, Peng Lu, Youwen Qian, Kongying Lin, Zeya Pan, Wan Yee Lau, Weiping Zhou
Our study indicated pathological responses (PR) ≥90% was an independent protective factor of incidences of MVI and prognosis; while PR<60% was an independent risk factor of incidences of MVI and prognosis. Patients with PR <60% were more likely to develop multiple recurrences.

Review Article

Extrahepatic organs in the development of non-alcoholic fatty liver disease in liver transplant patients
Renyi Su, Xuyong Wei, Qiang Wei, Di Lu, Zuyuan Lin, Shuo Wang, Chuxiao Shao, Xiao Xu
We propose 3 possible extrahepatic organs that participate in the NAFLD development process in LT patients. Potential mechanisms of NAFLD in LT context and current limitations in preclinical and clinical scenarios are discussed with suggestions for future study.


Neutrophil extracellular traps contribute to the development of hepatocellular carcinoma in NASH by promoting Treg differentiation
Rallia-Iliana Velliou, Ioannis Mitroulis, Antonios Chatzigeorgiou
The role of diet in the management of MAFLD—why does a new disease require a novel, individualized approach?
Alina Kurylowicz
Editorial on “Perihilar Cholangiocarcinoma—Novel Benchmark Values for Surgical and Oncological Outcomes From 24 Expert Centers
Shivan Sivakumar, Flavio G. Rocha, Lara Heij
Liver transplantation in the era of non-alcoholic fatty liver disease/metabolic (dysfunction) associated fatty liver disease: the dilemma of the steatotic liver graft on transplantation and recipient survival
Seren M. Gedallovich, Daniela P. Ladner, Lisa B. VanWagner
Could “Eating Behavior” be a novel lifestyle factor that modulates risk of gastrointestinal cancers?
Jonathan Q. Trinh, Faraz Bishehsari
Pan-peroxisome proliferator-activated receptor agonist lanifibranor as a dominant candidate pharmacological therapy for nonalcoholic fatty liver disease
Masato Yoneda, Takashi Kobayashi, Nogami Asako, Michihiro Iwaki, Satoru Saito, Atsushi Nakajima
Potential of extracellular vesicles and exosomes as diagnostic markers for cholangiocarcinoma
Linping Cao, Jiawei Hong, Jian Wu
NAFLD or MAFLD: the data behind the debate
Frederick Yick, Kaveh Hajifathalian
Identification and treatment of biliary complications after liver transplantation: more relevant than ever
Simon Moosburner, Johann Pratschke, Nathanael Raschzok
Utility of liver resection for breast cancer liver metastases, time for action
Karan Rangarajan, Zaed Z. R. Hamady
Genomic alterations in hepatocellular carcinoma and their clinical application to genomic medicine
Taisuke Imamura, Yukiyasu Okamura
Editorial comment: a review on radiofrequency, microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis
Merve Ozen, Driss Raissi
Developments in diagnosis and management of post-liver transplantation biliary complications: the radiologist’s perspective
Paolo Marra, Pietro Andrea Bonaffini, Davide Ippolito, Sandro Sironi
Developing a new nomogram to predict early allograft dysfunction after liver transplantation: a nudge in the right direction
Gang Xu, Chen-Hao Jiang, Tao Lv, Jiu-Lin Song, Yong-Jie Zhou, Jian Yang, Li Jiang, Lyu-Nan Yan, Kui Luo, Jia-Yin Yang
Editorial on “Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy: a systematic review”
Anastasia Murtha-Lemekhova, Katrin Hoffmann
Editorial on “Short- and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma: does left or right side matter?
Christian Benzing, Johann Pratschke, Moritz Schmelzle
The challenge of hepatic vein reconstruction in surgical oncology
Víctor Lopez-Lopez, David Ferreras, Dilmurodjon Eshmuminov, Roberto Brusadin, Ricardo Robles-Campos
The impact of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) on liver tumors with unusual indications
Kensuke Yamamura, Toru Beppu, Tatsunori Miyata, Shinichi Akahoshi, Takatoshi Ishiko

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini


Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.

Original Article

Review Article