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Original Article

Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma—a cost-effectiveness analysis
Kevin K. W. Chu, Albert C. Y. Chan, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Kenneth S. H. Chok, Tan To Cheung, Chung Mau Lo
Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP ≥400ng/ml or bilobar disease. Its routine use in preoperative workup for all HCC patients is not recommended because unilobar disease with AFP <400ng/ml has good negative predictive value.
Liver transplantation: would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?
Ka Wing Ma, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Wong Hoi She, Tan To Cheung, Wing Chiu Dai, James Yan Yue Fung, Chung Mau Lo
Although PVTT in HCC has been considered a sinister feature and hence a contraindication for LT for the sake of better liver graft utility, this study demonstrates that LT can confer much better oncological outcomes compared to hepatectomy in the context of HCC with PVTT.
A simple scoring system to estimate perioperative mortality following liver resection for primary liver malignancy—the Hepatectomy Risk Score (HeRS)
Dimitrios Moris, Brian I. Shaw, Cecilia Ong, Ashton Connor, Mariya L. Samoylova, Samuel J. Kesseli, Nader Abraham, Jared Gloria, Robin Schmitz, Zachary W. Fitch, Bryan M. Clary, Andrew S. Barbas
The Hepatectomy Risk Score (HeRS) incorporates the extent of resection and a MELD-Na score category to predict 30-day mortality after resection of primary liver malignancy. More complicated models offer better performance but at the expense of being more difficult to integrate into clinical practice.
The beneficial impacts of splanchnic vasoactive agents on hepatic functional recovery in massive hepatectomy porcine model
Hye-Sung Jo, Jae Hyun Han, Yoon Young Choi, Jin-I Seok, Young-In Yoon, Dong-Sik Kim
Excessive postoperative portal pressure, a major cause of post-hepatectomy liver failure and small-for-size syndrome after partial liver transplantation, is a difficult problem to be solved. Pharmacologic portal modulation with splanchnic vasoactive agents could optimize liver regeneration and attenuate liver injury after massive hepatectomy.

Review Article

Liver tissue microbiota in nonalcoholic liver disease: a change in the paradigm of host-bacterial interactions
Silvia Sookoian, Carlos J. Pirola
We highlight the evidence on the role of non-intestinal microbiotas in liver diseases with emphasis on liver tissue bacterial DNA in the biology of NAFLD and NASH. Also, we provide evidence of metagenomic findings that can be leveraged to discover novel therapeutic targets.
Optimization of the future remnant liver: review of the current strategies in Europe
Riccardo Memeo, Maria Conticchio, Emmanuel Deshayes, Silvio Nadalin, Astrid Herrero, Boris Guiu, Fabrizio Panaro

Viewpoint

Long-term health-related quality of life of living liver donors: what should the transplant team know?
Kohei Ogawa, Katsunori Sakamoto, Yasutsugu Takada
Refining the surgical playbook for treating colorectal cancer liver metastases
Luis I. Ruffolo, Roberto Hernandez-Alejandro, Koji Tomiyama
Expert consensus on magnetic recanalization technique for biliary anastomotic strictures after liver transplantation
Yu Li, Nan Zhang, Yi Lv, Scientific Committee of the Third International Conference of Magnetic Surgery
The role of the robot-assisted procedure during total pancreatectomy: a viewpoint
Matteo De Pastena, Alessandro Esposito, Roberto Salvia
Are probiotics effective in reversing non-alcoholic steatohepatitis?
Ludovico Abenavoli, Luigi Boccuto, Emidio Scarpellini
Management of neuroendocrine liver metastasis: Searching for new prognostic factor and appraising repeat hepatectomy
Junichi Arita, Sho Kiritani, Kiyoshi Hasegawa
Interpatient heterogeneity in hepatic microvascular blood flow during vascular inflow occlusion (Pringle manoeuvre)
Eric Felli, Edoardo Maria Muttillo, Emanuele Felli
Can endoscopic therapy help surgeons to manage post-hepatectomy bile leaks?
Massimiliano Mutignani, Lorenzo Dioscoridi

Disclosure:

1. The series “French Editorial from the ACHBPT” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.

2. The series “Images in Clinical Medicine” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini

Editorials

Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.



Original Article


Review Article


Letter to the Editor



Viewpoint


The Story Behind the Cover Picture