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Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition)

Therapeutic advances in advanced hepatocellular carcinoma have increased the opportunity for patients with initially unresectable disease to achieve tumor downstaging and undergo surgical resection, a ‘conversion therapy’. We reviewed current evidence for conversion therapy in HCC and developed expert consensus statements to guide clinical practice.

A novel radiomics signature based on T2-weighted imaging accurately predicts hepatic inflammation in individuals with biopsy-proven nonalcoholic fatty liver disease: a derivation and independent validation study

This is the largest single study to assess the prediction of histologic hepatic inflammation by radiomics in NAFLD to date. A radiomics signature based on T2 weighted magnetic resonance imaging non-invasively and accurately identifies severe hepatic inflammation in patients with biopsy-proven NAFLD.

Latest Impact Factor for Hepatobiliary Surgery and Nutrition: 7.293

We are pleased to announce that Hepatobiliary Surgery and Nutrition (HBSN) has obtained its latest impact factor for the 2020 citation year: 7.293.

CONGRATULATIONS to Yuman Fong, our senior editorial board member, also a friend of us, elected to National Academy of Medicine

Yuman Fong, M.D., the Sangiacomo Family Chair in Surgical Oncology at City of Hope, a world-renowned cancer research and treatment organization, was presented with one of the highest honors in health and medicine today.

The National Academy of Medicine (NAM) honored Fong “for transforming the fields of liver surgery, robotics in surgery, imaging and display in medicine, and gene therapy.” His contributions as a surgeon, engineer, innovator and mentor have yielded patents and first-in-human trials that translated scientific discoveries to medicines and medical devices.

Hepatobiliary Surgery and Nutrition (HBSN) is now a member of Committee on Publication Ethics (COPE)

Starting from July 2021, AME Publishing Company is formally recognized a publisher member of Committee on Publication Ethics (COPE) and over 60 AME-published journals become a member of Committee on Publication Ethics (COPE), as part of AME’s commitment to best practice in scholarly publishing. Hepatobiliary Surgery and Nutrition (HBSN) is among the list of COPE membership.

Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable

During liver transplantation, when the recipient’s hepatic artery is unusable, an arterial anastomosis performed on the recipient’s splenic or coeliac trunk is associated with better intraoperative and postoperative outcomes.

Gd-EOB-DTPA-enhanced MRI radiomic features for predicting histological grade of hepatocellular carcinoma

Radiomic features based on Gd-EOB-DTPA-enhanced MRI performed well in predicting histological grade of hepatocellular carcinoma, with AUCs of 0.777 to 0.944. Compared with traditional logistic regression model, Artificial neural network showed potential advantages in distinguishing between high-grade and low-grade HCCs.

Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria: a meta-analysis of 18,421 patients

LR was associated with poorer OS (HR 1.44, CI: 1.14-1.81, p<0.01) and DFS (HR 2.71, CI: 2.23-3.28, p<0.01) compared to LT. In uninodular HCC, OS was comparable between LR and LT (p=0.13), but DFS remained poorer (p<0.01). Cohorts that underwent enhanced surveillance had comparable OS between LR and LT (p=0.33).

Associating liver partition and portal vein ligation for staged hepatectomy versus sequential transarterial chemoembolization and portal vein embolization in staged hepatectomy for HBV-related hepatocellular carcinoma: a randomized comparative study

This article provides relatively high-level evidence about the merits and demerits of ALPPS compared with PVE, especially in patients with HBV related HCC, pointing out the higher resection rates and longer OS of ALPPS at the cost of a higher postoperative morbidity rate.

Development and internal validation of the Comprehensive ALPPS Preoperative Risk Assessment (CAPRA) score: is the patient suitable for Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS)?

The CAPRA Score, based on patient condition and type of procedure, has excellent preoperative prediction of 90-day mortality risk in ALPPS. It therefore provides additional support in patient selection and procedure planning, in combination with already validated scores, volumetry and liver function assessments.

Intraoperative reperfusion assessment of human pancreas allografts using hyperspectral imaging (HSI)

This article describes the first application of hyperspectral imaging in human pancreas allografts. Our novel non-invasive technique is capable to deliver real time visual and quantitative information about the tissue oxygenation, perfusion as well as hemoglobin and water concentration of the organ, subject to investigation.

Preservation of aberrant right hepatic arteries does not affect safety and oncological radicality of pancreaticoduodenectomy—own results and a systematic review of the literature

The aim of the present study was to investigate the incidence and management of aRHA in a large cohort of consecutive PD and to assess its effect on the surgical and oncological outcomes, and to compare the results to those already available in the literature.

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Vol 11, No 3 (June, 2022)

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Original Article

Impact of living donor liver with steatosis and idiopathic portal inflammation on clinical outcomes in pediatric liver transplantation: Beijing experience

Xinyan Zhao, Yafei He, Jimin Liu, Qian Zhang, Liwei Liu, Wei Qu, Ying Liu, Zhigui Zeng, Haiming Zhang, Jidong Jia, Liying Sun, Lin Wei, Zhijun Zhu

PDF Pages: 340-354 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

This study provided new evidence in pediatric living donor liver allocation. Donor liver with mild portal inflammation would better not be allocated to recipients with high pediatric-end-stage-liver-disease score.

Peripancreatic vascular involvement in patients with type 1 autoimmune pancreatitis

Meizi Li, Xiaoyin Bai, Kai Xu, Xi Wu, Tao Guo, Qingwei Jiang, Qiang Wang, Shengyu Zhang, Yingyun Yang, Yunlu Feng, Aiming Yang

PDF Pages: 355-362 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

This study revealed the real-world condition of peripancreatic vascular involvement (PVI) in patients with type 1 autoimmune pancreatitis (AIP) and described independent predictors of PVI development in AIP patients. The follow-up showed majority of PVI lesions achieved an improvement after corticosteroid treatment.

Have we really understood when the efforts of laparoscopic liver resection are justified?—a complexity-based appraisal of the differential benefit

Francesca Ratti, Federica Cipriani, Guido Fiorentini, Marco Catena, Michele Paganelli, Luca Aldrighetti

PDF Pages: 363-374 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

The favorable biological scenario associated with laparoscopy allows to obtain significant benefits in the setting of complex procedures, constituting the prerequisite for adequate surgical outcome. The effort should be to maximize the laparoscopic approach in high complexity procedures by implementing surgical technique and perioperative management.

Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma

Takehiro Noji, Satoko Uemura, Jimme K. Wiggers, Kimitaka Tanaka, Yoshitsugu Nakanishi, Toshimichi Asano, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Pim B. Olthof, William R. Jarnagin, Thomas M. van Gulik, Satoshi Hirano

PDF Pages: 375-385 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

We validate postoperative liver failure (PHLFS) and mortality risk scores (POMRS) after liver resection for perihilar cholangiocarcinoma, which was established by Western cohort, by Eastern cohort. This external validation study showed that for PHLFS the threshold for discrimination, but the POMRS were not applicable.

Impact of pathological response after preoperative transcatheter arterial chemoembolization (TACE) on incidences of microvascular invasion and early tumor recurrence in hepatocellular carcinoma: a multicenter propensity score matching analysis

Yun Yang, Zheng Dang, Peng Lu, Youwen Qian, Kongying Lin, Zeya Pan, Wan Yee Lau, Weiping Zhou

PDF Pages: 386-399 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Our study indicated pathological responses (PR) ≥90% was an independent protective factor of incidences of MVI and prognosis; while PR<60% was an independent risk factor of incidences of MVI and prognosis. Patients with PR <60% were more likely to develop multiple recurrences.

Review Article

Extrahepatic organs in the development of non-alcoholic fatty liver disease in liver transplant patients

Renyi Su, Xuyong Wei, Qiang Wei, Di Lu, Zuyuan Lin, Shuo Wang, Chuxiao Shao, Xiao Xu

PDF Pages: 400-411 Full Text Reporting Checklist COI Form Open Access

We propose 3 possible extrahepatic organs that participate in the NAFLD development process in LT patients. Potential mechanisms of NAFLD in LT context and current limitations in preclinical and clinical scenarios are discussed with suggestions for future study.

Editorial from the ACHBPT

Patient with unresectable colorectal liver metastases and asymptomatic primary tumor: end of the debate!

Marc-Antoine Allard, René Adam

PDF Pages: 412-414 Full Text COI Form Open Access

Editorial

Neutrophil extracellular traps contribute to the development of hepatocellular carcinoma in NASH by promoting Treg differentiation

Rallia-Iliana Velliou, Ioannis Mitroulis, Antonios Chatzigeorgiou

PDF Pages: 415-418 Full Text COI Form Open Access

The role of diet in the management of MAFLD—why does a new disease require a novel, individualized approach?

Alina Kurylowicz

PDF Pages: 419-421 Full Text COI Form Open Access

Editorial on “Perihilar Cholangiocarcinoma—Novel Benchmark Values for Surgical and Oncological Outcomes From 24 Expert Centers”

Shivan Sivakumar, Flavio G. Rocha, Lara Heij

PDF Pages: 422-424 Full Text COI Form Open Access

Liver transplantation in the era of non-alcoholic fatty liver disease/metabolic (dysfunction) associated fatty liver disease: the dilemma of the steatotic liver graft on transplantation and recipient survival

Seren M. Gedallovich, Daniela P. Ladner, Lisa B. VanWagner

PDF Pages: 425-429 Full Text COI Form Open Access

Could “Eating Behavior” be a novel lifestyle factor that modulates risk of gastrointestinal cancers?

Jonathan Q. Trinh, Faraz Bishehsari

PDF Pages: 430-432 Full Text COI Form Open Access

Pan-peroxisome proliferator-activated receptor agonist lanifibranor as a dominant candidate pharmacological therapy for nonalcoholic fatty liver disease

Masato Yoneda, Takashi Kobayashi, Nogami Asako, Michihiro Iwaki, Satoru Saito, Atsushi Nakajima

PDF Pages: 433-435 Full Text COI Form Open Access

Potential of extracellular vesicles and exosomes as diagnostic markers for cholangiocarcinoma

Linping Cao, Jiawei Hong, Jian Wu

PDF Pages: 436-438 Full Text COI Form Open Access

NAFLD or MAFLD: the data behind the debate

Frederick Yick, Kaveh Hajifathalian

PDF Pages: 439-442 Full Text COI Form Open Access

Identification and treatment of biliary complications after liver transplantation: more relevant than ever

Simon Moosburner, Johann Pratschke, Nathanael Raschzok

PDF Pages: 443-445 Full Text COI Form Open Access

Utility of liver resection for breast cancer liver metastases, time for action

Karan Rangarajan, Zaed Z. R. Hamady

PDF Pages: 446-448 Full Text COI Form Open Access

Genomic alterations in hepatocellular carcinoma and their clinical application to genomic medicine

Taisuke Imamura, Yukiyasu Okamura

PDF Pages: 449-452 Full Text COI Form Open Access

Editorial comment: a review on radiofrequency, microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis

Merve Ozen, Driss Raissi

PDF Pages: 453-456 Full Text COI Form Open Access

Developments in diagnosis and management of post-liver transplantation biliary complications: the radiologist’s perspective

Paolo Marra, Pietro Andrea Bonaffini, Davide Ippolito, Sandro Sironi

PDF Pages: 457-461 Full Text COI Form Open Access

Developing a new nomogram to predict early allograft dysfunction after liver transplantation: a nudge in the right direction

Gang Xu, Chen-Hao Jiang, Tao Lv, Jiu-Lin Song, Yong-Jie Zhou, Jian Yang, Li Jiang, Lyu-Nan Yan, Kui Luo, Jia-Yin Yang

PDF Pages: 462-466 Full Text COI Form Open Access

Editorial on “Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy: a systematic review”

Anastasia Murtha-Lemekhova, Katrin Hoffmann

PDF Pages: 467-469 Full Text COI Form Open Access

Editorial on “Short- and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma: does left or right side matter?”

Christian Benzing, Johann Pratschke, Moritz Schmelzle

PDF Pages: 470-472 Full Text COI Form Open Access

The challenge of hepatic vein reconstruction in surgical oncology

Víctor Lopez-Lopez, David Ferreras, Dilmurodjon Eshmuminov, Roberto Brusadin, Ricardo Robles-Campos

PDF Pages: 473-476 Full Text COI Form Open Access

The impact of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) on liver tumors with unusual indications

Kensuke Yamamura, Toru Beppu, Tatsunori Miyata, Shinichi Akahoshi, Takatoshi Ishiko

PDF Pages: 477-480 Full Text COI Form Open Access

Commentary

Is it necessary to target lipid metabolism in different organs for effective treatment of NASH?—the results of the Pan-PPAR Lanifibranor trial

Amalia Gastaldelli

PDF Pages: 481-484 Full Text COI Form Open Access

Hepatocellular carcinoma as the Rose of Jericho: from the desert of sorafenib, to the blossoming of immunotherapy

Antonio D’Alessio, Lorenza Rimassa

PDF Pages: 485-488 Full Text COI Form Open Access

Robotic pancreaticoduodenectomy after the learning curve—a new hope

Philip C. Müller, Beat P. Müller-Stich, Thilo Hackert, Felix Nickel

PDF Pages: 489-491 Full Text COI Form Open Access

Risk factors for non-alcoholic fatty liver disease delineate the battlegrounds in optimizing disease prevention

Igor Spivak, Eran Elinav

PDF Pages: 492-494 Full Text COI Form Open Access

Letter to the Editor

Development and internal validation of the Comprehensive ALPPS Preoperative Risk Assessment (CAPRA) score

Junwei Zhang, Huayu Yang, Xin Lu, Yiyao Xu

PDF Pages: 495-497 Full Text COI Form Open Access

Living donor liver transplantation combined with splenectomy in a child with Niemann-Pick disease type B: single-centre experience of perioperative anticoagulation regimen

Han Ding, Jian Wang, Yichi Zhang, Shuai Zhao, Bing Han, Hao Cai, Jinyang Gu

PDF Pages: 498-501 Full Text COI Form Open Access

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings

Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis

Liver transplantation for hepatocellular carcinoma

Jerome Byam, John Renz, J. Michael Millis

Hilar cholangiocarcinoma: diagnosis, treatment options, and management

Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors

Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa

Diagnosis and treatment of hepatic angiomyolipoma

Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang

Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report

Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats

Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Review Articles

Selection of patients of hepatocellular carcinoma beyond the Milan criteria for liver transplantation

See Ching Chan, Sheung Tat Fan

Selection of patients of hepatocellular carcinoma beyond the Milan criteria for liver transplantation

See Ching Chan, Sheung Tat Fan

Perspectives

Chemoprevention and novel therapy for hepatocellular carcinoma associated with chronic hepatitis B virus infection

Ih-Jen Su, Wen-Chuan Hsieh, Hung-Wen Tsai, Han-Chieh Wu

Original Article

Real-time 3D image reconstruction guidance in liver resection surgery

Luc Soler, Stephane Nicolau, Patrick Pessaux, Didier Mutter, Jacques Marescaux

Review Article

Hilar cholangiocarcinoma: diagnosis, treatment options, and management

Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Gallbladder cancer

Mislav Rakic, Leonardo Patrlj, Mario Kopljar, Robert Klicek, Marijan Kolovrat, Bozo Loncar, Zeljko Busic

The multifaceted nature of retinoid transport and metabolism

Yang Li, Nuttaporn Wongsiriroj, William S. Blaner

Small for size liver remnant following resection: prevention and management

Rony Eshkenazy, Yael Dreznik, Eylon Lahat, Barak Bar Zakai, Alex Zendel, Arie Ariche

Liver transplantation for hepatocellular carcinoma

Jerome Byam, John Renz, J. Michael Millis

Perspective

Perspectives on using des-γ-carboxyprothrombin (DCP) as a serum biomarker: facilitating early detection of hepatocellular carcinoma in China

Peipei Song, Xiaobin Feng, Keming Zhang, Tianqiang Song, Kuansheng Ma, Norihiro Kokudo, Jiahong Dong, Wei Tang

Original Articles

Serum VEGF level is associated with the outcome of patients with hepatocellular carcinoma: a meta-analysis

Ping Zhan, Qian Qian, Li-Ke Yu

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats

Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions

Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Prognostic significance of vascular endothelial growth factor expression in hepatocellular carcinoma tissue: a meta-analysis

Ping Zhan, Qian Qian, Li-Ke Yu

Review Articles

Cholangiocarcinoma: increasing burden of classifications

Vincenzo Cardinale, Maria Consiglia Bragazzi, Guido Carpino, Alessia Torrice, Alice Fraveto, Raffaele Gentile, Vincenzo Pasqualino, Fabio Melandro, Camilla Aliberti, Carlo Bastianelli, Roberto Brunelli, Pasquale Bartolomeo Berloco, Eugenio Gaudio, Domenico Alvaro

Review Articles on Liver Immunology: Part 1

Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology

Ralf Weiskirchen, Frank Tacke

Immune mechanisms in acetaminophen-induced acute liver failure

Oliver Krenkel, Jana C. Mossanen, Frank Tacke

Therapeutic targeting of liver inflammation and fibrosis by nanomedicine

Matthias Bartneck, Klaudia Theresa Warzecha, Frank Tacke

Immunomodulatory effects of transforming growth factor-β in the liver

Hans-Theo Schon, Ralf Weiskirchen

Review Articles on Liver Immunology: Part 2

The role of miRNAs in the regulation of inflammatory processes during hepatofibrogenesis

Sanchari Roy, Fabian Benz, Tom Luedde, Christoph Roderburg

Review Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction

Metin Basaranoglu, Gokcen Basaranoglu, Elisabetta Bugianesi

Fatty liver disease in diabetes mellitus

Harikrashna B. Bhatt, Robert J. Smith

Sirtuin 1 signaling and alcoholic fatty liver disease

Min You, Alvin Jogasuria, Charles Taylor, Jiashin Wu

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes

Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions

Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini

Editorials

Risk stratification for Hepatitis B treatment in the molecular age

Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats

Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions

Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis

Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice

Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis

Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux

Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats

Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.

Original Article

One- versus two-stage partial hepatectomy for large resectable solitary hepatocellular carcinomas determined preoperatively to have a narrow resection margin: a propensity score matching analysis

Yao Li, Peng-Peng Li, Da-Peng Sun, Jun-Sheng Ni, Hui Liu, Ze-Ya Pan, Yuan Yang, Ling-Hao Zhao, Wan Yee Lau, Gang Huang, Wei-Ping Zhou

The role of intraoperative electron radiotherapy in centrally located hepatocellular carcinomas treated with narrow-margin (<1 cm) hepatectomy: a prospective, phase 2 study

Liming Wang, Yunhe Liu, Weiqi Rong, Fan Wu, Weibo Yu, Kan Liu, Shengtao Lin, Yiling Zheng, Kai Zhang, Tana Siqin, Changcheng Tao, Mei Liu, Bo Chen, Qinfu Feng, Jianxiong Wu

Epigenome-wide development and validation of a prognostic methylation score in intrahepatic cholangiocarcinoma based on machine learning strategies

Xing Chen, Liangqing Dong, Lu Chen, Yuan Wang, Jinpeng Du, Lijie Ma, Xiaokai Yan, Jiwei Huang, Mingheng Liao, Xiangzheng Chen, Dongming Liu, Jin Li, Bo Zhang, Wen Teng, Kefei Yuan, Deqiang Sun, Qiang Gao, Yong Zeng

Functional assessment of liver regeneration after major hepatectomy

Fadi Rassam, Pim B. Olthof, Bart Takkenberg, Marc G. Besselink, Olivier R. Busch, Joris I. Erdmann, Rutger-Jan Swijnenburg, Krijn P. van Lienden, Ulrich H. Beuers, Roelof J. Bennink, Thomas M. van Gulik

Combined non-alcoholic fatty liver disease and type 2 diabetes in severely obese patients—medium term effects of sleeve gastrectomy versus Roux-en-Y-gastric bypass on disease markers

Franck Billmann, Sherehan El Shishtawi, Tom Bruckner, Mostafa ElSheikh, Beat Peter Müller-Stich, Adrian Billeter

Prospective evaluation of ¹⁸F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

Tim Akhurst, Mithat Gönen, Raymond E. Baser, Lawrence H. Schwartz, Scott Tuorto, Lynn A. Brody, Anne Covey, Karen T. Brown, Steven M. Larson, Yuman Fong

International assessment and validation of the prognostic role of lymph node ratio in patients with resected pancreatic head ductal adenocarcinoma

Gaëtan-Romain Joliat, Ismail Labgaa, Jesse Sulzer, Dionisios Vrochides, Alessandro Zerbi, Gennaro Nappo, Julie Perinel, Mustapha Adham, Stijn van Roessel, Marc G. Besselink, J. Sven D. Mieog, Jesse V. Groen, Nicolas Demartines, Markus Schäfer

Highly variable biodistribution of ⁶⁸Ga labeled somatostatin analogues ⁶⁸Ga-DOTA-NOC and ⁶⁸Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT

Monica Cheng, Mark Tann

Automated liver tumor detection in abdominal ultrasonography with a modified faster region-based convolutional neural networks (Faster R-CNN) architecture

Kenji Karako, Yuichiro Mihara, Junichi Arita, Akihiko Ichida, Sung Kwan Bae, Yoshikuni Kawaguchi, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Kiyoshi Hasegawa, Yu Chen

Nab-paclitaxel plus tegafur gimeracil oteracil potassium capsule (S-1) as first-line treatment for advanced biliary tract adenocarcinoma: a phase 2 clinical trial

Wen Zhang, Yongkun Sun, Zhichao Jiang, Wang Qu, Caifeng Gong, Aiping Zhou

Transcatheter arterial embolization-salvaged ALPPS, a novel ALPPS procedure especially for patients with hepatocellular carcinoma and severe fibrosis/cirrhosis

Yuanfei Peng, Zheng Wang, Xudong Qu, Feiyu Chen, Huichuan Sun, Xiaoying Wang, Zhenbing Ding, Min Tang, Lei Yu, Xinrong Yang, Qiang Gao, Zhaoyou Tang, Wan Yee Lau, Jia Fan, Jian Zhou

The influence of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography on the N- and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma

Youpei Lin, Huanhuan Chong, Guohe Song, Chenhao Zhang, Liangqing Dong, Ling Aye, Fei Liang, Shuaixi Yang, Mengsu Zeng, Guangyu Ding, Shu Zhang, Jieyi Shi, Aiwu Ke, Xiaoying Wang, Jian Zhou, Jia Fan, Qiang Gao

Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study

Moritz Schmelzle, Felix Krenzien, Paul Dahlke, Alina Krombholz, Nora Nevermann, Linda Feldbrügge, Axel Winter, Wenzel Schöning, Christian Benzing, Johann Pratschke, Jens Neudecker

Targeted deep sequencing reveals the genetic heterogeneity in well-differentiated pancreatic neuroendocrine tumors with liver metastasis

Wentao Zhou, Xu Han, Yuan Ji, Dansong Wang, Dong Xie, Zilong Qiu, Wenhui Lou

Predictors and long-term prognosis of early and late recurrence for patients undergoing hepatic resection of hepatocellular carcinoma: a large-scale multicenter study

Wen-Tao Yan, Chao Li, Lan-Qing Yao, Hai-Bo Qiu, Ming-Da Wang, Xin-Fei Xu, Ya-Hao Zhou, Hong Wang, Ting-Hao Chen, Wei-Min Gu, Jian-Hong Zhong, Han Wu, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang

Association of tumor morphology with long-term prognosis after liver resection for patients with a solitary huge hepatocellular carcinoma—a multicenter propensity score matching analysis

Xin-Fei Xu, Han Wu, Ju-Dong Li, Lan-Qing Yao, Bin Huang, Yong-Kang Diao, Ting-Hao Chen, Wei-Min Gu, Zhong Chen, Jie Li, Yao-Ming Zhang, Hong Wang, Ying-Jian Liang, Ya-Hao Zhou, Chao Li, Ming-Da Wang, Cheng-Wu Zhang, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang

Propensity score matching study of 325 patients with spontaneous rupture of hepatocellular carcinoma

Wei Wang, Tao Meng, Ying Chen, Ye-Chuan Xu, Yi-Jun Zhao, Yan Zhang, Ming-Ya Yang, Zhi-Hua Zhang, Fan Huang, Hong-Chuan Zhao, Xiao-Ping Geng, Li-Xin Zhu

Serum metabolic effects of corn oligopeptides with 7-day supplementation on early post-surgery primary liver cancer patients: a double-blind randomized controlled trial

Weiqi Rong, Hui Xia, Kai Zhang, Yihan Zhang, Changcheng Tao, Fan Wu, Liming Wang, Hong Zhang, Guiju Sun, Jianxiong Wu

Microvascular invasion of hepatocellular carcinoma predicts microvascular invasion of its recurrence: potential implications for salvage liver transplantation?

Stefan Heinrich, Jens Mittler, Juliane Theurer, Dirk A. Ridder, Jens U. Marquardt, Arndt Weinmann, Uwe Scheuermann, Gerd Otto, Peter R. Galle, Beate K. Straub, Hauke Lang

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma incidence between 2006 and 2015 in China: estimates based on data from 188 population-based cancer registries

Lan An, Rongshou Zheng, Siwei Zhang, Ru Chen, Shaoming Wang, Kexin Sun, Lingeng Lu, Xuehong Zhang, Hong Zhao, Hongmei Zeng, Wenqiang Wei, Jie He

Nonalcoholic steatohepatitis critically rewires the ischemia/reperfusion-induced dysregulation of cardiolipins and sphingolipids in mice

Sheng Yu, Kai Wang, Qingping Li, Yiran Wei, Yiyi Li, Qifan Zhang, Pengxiang Huang, Hanbiao Liang, Hang Sun, Hongxian Peng, Xixin Huang, Cuiting Liu, Jie Zhou, Jianping Qian, Chuanjiang Li

Living donor liver transplantation for Barcelona clinic liver cancer (BCLC) intermediate-stage hepatocellular carcinoma

Ming Chao Tsai, Chee-Chien Yong, Chih-Che Lin, Wei-Chen Lee, Chih-Chi Wang, Chao-Hung Hung, I-Hsuan Chen, Yu-Fan Cheng, Chang-Chun Hsiao, Tsung-Hui Hu, Chao-Long Chen

Review Article

A review of the current and future role of robotic surgery in liver surgery and transplantation

Michele Finotti, Francesco D’Amico, David Mulligan, Giuliano Testa

The Hong Kong consensus statements on unresectable hepatocellular carcinoma: narrative review and update for 2021

Tan-To Cheung, Simon Chun-Ho Yu, Stephen L. Chan, Ronnie T. P. Poon, Philip Kwok, Ann-Shing Lee, Anna Tai, Derek Tam, Chin-Cheung Cheung, Tak-Wing Lai, Nam-Hung Chia, Ada Law, Tracy Shum, Yim-Kwan Lam, Vince Lau, Victor Lee, Charing Chong, Chung-Ngai Tang, Thomas Yau

Cholangiocarcinoma: a review of the literature and future directions in therapy

Ritika Halder, Akshay Amaraneni, Rachna T. Shroff

Comparative effectiveness of medical treatment vs. metabolic surgery for histologically proven non-alcoholic steatohepatitis and fibrosis: a matched network meta-analysis

Adrian T. Billeter, Beatrice Reiners, Svenja E. Seide, Pascal Probst, Eva Kalkum, Christian Rupp, Beat P. Müller-Stich

Assessment of robustness of randomized controlled trials for the treatment of cholangiocarcinoma in three domains: survival-inferred fragility index, restricted mean survival time, and the spin effect

Nir Horesh, David Bomze, Chetana Lim, Gal Markel, Tomer Meirson, Daniel Azoulay

Neoadjuvant radiotherapy for resectable hepatocellular carcinoma with portal vein tumor thrombus: a systematic review

Zhewen Wei, Jianjun Zhao, Xinyu Bi, Yefan Zhang, Jianguo Zhou, Zhiyu Li, Zhen Huang, Hong Zhao, Jianqiang Cai

Alternatives to left lateral sector in paediatric liver transplantation—a systematic review on monosegmental and reduced grafts

Paschalis Gavriilidis, Ernest Hidalgo

Journal Highlight more

The Hepatobiliary Surgery and Nutrition is an international, open access, peer-reviewed journal indexed in PubMed and Science Citation Index Expanded (SCIE), covering the field of surgical techniques, clinical and basic researches, transplantation and other therapies, related imaging, biology, pathology, immunology, targeted drug and molecular developments and technical advances, etc.

Indexing

In Science Citation Index Expanded (SCIE)

In PubMed

In PMC

Membership

Ownership and Management

Hepatobiliary Surgery and Nutrition is published, owned and managed by AME Publishing Company

Society for Translational Medicine (STM), Hong Kong

About hbsn

Manuscript Submission

AME Editing Service

Reprint & Permission

Contact us

General editorial enquiries:

Copyright related contact:

Commercial Sales contact (Reprints, advertising, etc.):

Original Article

Review Article

Editorial from the ACHBPT

Editorial

Commentary

Letter to the Editor

Review Article

Original Articles

Review Articles

Perspectives

Original Article

Review Article

Perspective

Original Articles

Review Articles

Review Articles on Liver Immunology: Part 1

Review Articles on Liver Immunology: Part 2

Review Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Original Article

Review Article

Editorials

Original Articles

Review Articles on Liver Immunology: Part 2

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

Review Article on Retinoid Biology: Part I

Original Article on Retinoid Biology: Part I

Original Article

Review Article