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The Story Behind the Cover Picture1

Background story of the cover picture
Thomas van Gulik

Original Article

Prospective study to evaluate the prognostic value of different nutritional assessment scores in liver surgery: NURIMAS Liver (DRKS00006340)
Pascal Probst, Juri Fuchs, Michael R. Schön, Georgios Polychronidis, Christos Stravodimos, Arianeb Mehrabi, Markus K. Diener, Philipp Knebel, Markus W. Büchler, Katrin Hoffmann
In this prospective observational cohort study, the association of malnutrition and complications in liver surgery was investigated. Twelve different commonly used nutritional assessment score were tested. None of the scores proofed to be an independent predictor of morbidity. Other methods should be investigated in future trials to assess the impact of nutritional status in liver surgery.
Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma
Jianzhen Lin, Xu Yang, Junyu Long, Songhui Zhao, Jinzhu Mao, Dongxu Wang, Yi Bai, Jin Bian, Lei Zhang, Xiaobo Yang, Anqiang Wang, Fucun Xie, Weiwei Shi, Huayu Yang, Jie Pan, Ke Hu, Mei Guan, Lin Zhao, Li Huo, Yilei Mao, Xinting Sang, Kai Wang, Haitao Zhao
Co-inhibition targeting anti-angiogenesis and PD-1/PDL1 signaling shows potent antitumor efficacy in many solid tumors. This study preliminarily demonstrated that the therapeutic strategy with lenvatinib plus pembrolizumab is a promising and safe regimen from a single center cohort enrolled 32 patients with advanced biliary tract cancers.
New-onset diabetes after adult liver transplantation in the Korean Organ Transplantation Registry (KOTRY) study
Jong Man Kim, Shin Hwang, Kwang-Woong Lee, Jae-Geun Lee, Je Ho Ryu, Bong-Wan Kim, Dong Lak Choi, Young Kyoung You, Dong-Sik Kim, Yang Won Nah, Koo Jeong Kang, Jai Young Cho, Geun Hong, In Seok Choi, Hee Chul Yu, Dongho Choi, Myoung Soo Kim, The Korean Organ Transplantation Registry Study Group

Review Article

Neuroendocrine liver metastases: a contemporary review of treatment strategies
Jordan M. Cloyd, Aslam Ejaz, Bhavana Konda, Mina S. Makary, Timothy M. Pawlik
2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
The past decade has witnessed a great improvement in the management of hepatocellular carcinoma (HCC). This study reviews the recommendations in the 2019 Chinese guidelines and makes comparison with the practices from the Western world.
International expert consensus on laparoscopic pancreaticoduodenectomy*
Renyi Qin, Michael L. Kendrick, Christopher L. Wolfgang, Barish H. Edil, Chinnusamy Palanivelu, Rowan W. Parks, Yinmo Yang, Jin He, Taiping Zhang, Yiping Mou, Xianjun Yu, Bing Peng, Palanisamy Senthilnathan, Ho-Seong Han, Jae Hoon Lee, Michiaki Unno, Steven W. M. Olde Damink, Virinder Kumar Bansal, Pierce Chow, Tan To Cheung, Nim Choi, Yu-Wen Tien, Chengfeng Wang, Manson Fok, Xiujun Cai, Shengquan Zou, Shuyou Peng, Yupei Zhao
The present international consensus statement on the technical standards for laparoscopic pancreaticoduodenectomy (LPD) can be used to guide the continued safe progression and adoption of LPD. More robust randomized controlled trial and registry study are essential to proceed with the assessment of such technique.


Vessels encapsulating tumor clusters in hepatocellular carcinoma: a unique and valuable pathological imaging
Yo-ichi Yamashita, Hideo Baba
Faecal microbiota transplantation as an elixir of youth
Craig Haifer, Sudarshan Paramsothy, Rupert W. Leong
Refining selection criteria to further increase survival benefit in liver transplantation for unresectable colorectal liver metastases
Matteo Serenari, Matteo Ravaioli
Nonalcoholic fatty liver disease in type 2 diabetes: awareness is the first step toward change
Fernando Bril
Locally advanced pancreatic cancer: staging, operability, and the importance of multimodality therapy
Rebecca Y. Kim, Douglas B. Evans, Kathleen K. Christians
Perspectives on immunotherapy utilization for hepatobiliary cancers in the United States
Pedro Luiz Serrano Usón Junior, Daniel Ahn, Mohamad Bassam Sonbol, Tanios Bekaii-Saab, Mitesh J. Borad
Clinical outcomes after treatment with direct-acting antivirals: not all concern hepatocellular carcinoma risk
Elton Dajti, Federico Ravaioli, Davide Festi, Antonio Colecchia
Evaluating the application of next generation sequencing techniques in endoscopic retrograde cholangiopancreatography (ERCP) to improve diagnostic accuracy in patients with malignant biliary strictures
Tan To Cheung
Risk stratification of HCC occurrence after HCV eradication: a complicate plot of risk factors related and unrelated to the previous viral disease
Valentina Cossiga, Maria Guarino, Filomena Morisco, Nicola Caporaso
Nonalcoholic fatty liver disease and type 2 diabetes: a burgeoning problem with unclear solutions
Mariana Lazo, Jeanne M. Clark
Hepatocellular carcinoma and liver transplant: beyond the Milan criteria and the risk of “short-blanket” syndrome
Stefano Gitto, Stefano Di Sandro, Paolo Magistri, Pietro Andreone, Fabrizio Di Benedetto
The rapidly expanding role of thermal ablation in the treatment of colorectal liver metastases
Martijn R. Meijerink, M. Petrousjka van den Tol, Robbert S. Puijk
Probiotics and synbiotics targeting the intestinal microbiome attenuate non-alcoholic fatty liver disease
Luis Vitetta, Jeremy D. Henson
A new era of systemic therapy for intermediate and advanced stage hepatocellular carcinoma
Masatoshi Kudo
Pediatric NAFLD: lessons from the gut
Laura Iogna Prat, Emmanuel A. Tsochatzis


Challenges in elucidating cholangiocarcinoma etiology
Sarah S. Jackson, Andrea A. Florio, Katherine A. McGlynn, Jessica L. Petrick


1. The series "The Story Behind the Cover Picture" was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini


Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.


Original Article

Review Article