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Original Article

Interpatient heterogeneity in hepatic microvascular blood flow during vascular inflow occlusion (Pringle manoeuvre)
Lucinda Shen, Zühre Uz, Joanne Verheij, Denise P. Veelo, Yasin Ince, Can Ince, Thomas M. van Gulik
Many surgeons rely on vascular inflow occlusion (VIO) to reduce bood loss during liver resection. Real-time assessment of hepatic microcirculation during complete VIO in 15 patients revealed that half of the patients had persistent perfusion demonstrating an interpatient heterogeneous response to VIO.
Comparative long-term outcomes for pancreatic volume change, nutritional status, and incidence of new-onset diabetes between pancreatogastrostomy and pancreatojejunostomy after pancreaticoduodenectomy
Bong Jun Kwak, Ho Joong Choi, Young Kyoung You, Dong Goo Kim, Tae Ho Hong
This comparative cohort study demonstrated that pancreaticogastrostomy and pancreaticojejunostomy after pancreaticoduodenectomy induced similar pancreatic volume reduction during long-term follow-up. There was no difference in general nutritional status or incidence of new-onset diabetes between the groups.
Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer
Scott Kizy, Ariella M. Altman, Keith M. Wirth, Schelomo Marmor, Jane Y. C. Hui, Todd M. Tuttle, Emil Lou, Khalid Amin, Jason W. Denbo, Eric H. Jensen
This single-institution series found that chemotherapy without radiation is an effective neoadjuvant strategy prior to surgery for pancreas cancer. Multi-agent therapy was not associated with improved overall survival over less toxic, single agent regimens. Local progression of disease was not seen, despite the absence of radiation therapy.
Retrospective analysis of 45 cases of localized retroperitoneal Castleman disease from a single center
Jian-Qiang Tang, He-Kai Chen, Xin Wang, Ming-Yue Wang, Yan Xiong, He Wang, Yin-Mo Yang
Radical resection is critical to treating the retroperitoneal Castleman disease. Complication with paraneoplastic pemphigus, complication with bronchiolitis obliterans, male and age ≥40 years were identified as prognostic risk factors for patients with localized retroperitoneal Castleman disease.
Radioembolization for neuroendocrine liver metastases is safe and effective prior to major hepatic resection
Florian Bösch, Harun Ilhan, Vanessa Pfahler, Michael Thomas, Thomas Knösel, Valentin Eibl, Sebastian Pratschke, Peter Bartenstein, Max Seidensticker, Christoph J. Auernhammer, Christine Spitzweg, Markus O. Guba, Jens Werner, Martin K. Angele


SARS-CoV-2 and liver damage: a possible pathogenetic link
Ludovico Abenavoli, Ivan Gentile, Alberto Enrico Maraolo, Francesco Negro
Coronavirus disease 2019: implications for liver transplantation
Qiang Wei, Junbin Zhou, Tian Shen, Shusen Zheng, Xiao Xu
Creating favorable conditions for increased quantity of high-quality clinical studies in surgery
Tian Yang, Wan Yee Lau, Feng Shen
How to balance the development of new surgical techniques and protection of patients’ health interests
Xiao-Ping Geng
Liver transplantation for colorectal metastasis: a stepwise approach
Axel Andres, Christian Toso
Bilateral proficiency over time leads to reduced donor morbidity in living donor hepatectomy
Jan P. Lerut
Nutritional support treatment for perioperative patients in hepatobiliary surgery
Shuifang Jin, Ronglin Jiang, Xi Xing, Weibin Ma
Gut microbiota and hepatocellular carcinoma
Panzhi Wang, Kun Chen
Focus on immune-related adverse events (irAEs) in immunotherapy of hepatobiliary malignancies
Lei Zhang, Haitao Zhao
Dual angiogenesis and PD-1 blockade in hepatocellular carcinoma
Julien Calderaro
PNPLA3 and nonalcoholic fatty liver disease: towards personalized medicine for fatty liver
Liyun Yuan, Norah A. Terrrault
Diabetes and hepatocellular carcinoma risks in patients with nonalcoholic steatohepatitis related cirrhosis
Chien-Hsieh Chiang, Kuo-Chin Huang
Prudent use of a left hepatic graft in adult-to-adult living donor liver transplantation: aiming for further securing donors’ safety
Hideaki Uchiyama
Could hepatic ablation promote development of colon cancer hepatic metastases?
Crystal Kyaw, Joyce Wong
The future of adjuvant therapy in ampullary cancer: should we offer it to our patients?
Sri Harsha Tella, Amit Mahipal
Laparoscopic liver resections at the gates of 2020: a stand-alone field of hepatobiliary surgery
Federica Cipriani, Francesca Ratti, Luca Aldrighetti
Non-alcoholic fatty liver disease (NAFLD) diagnosis and management—differentiating the essential from the ancillary and the present from the future
Amedeo Lonardo, Simonetta Lugari, Fabio Nascimbeni
Mediterranean diet as the ideal model for preventing non-alcoholic fatty liver disease (NAFLD)
Miguel A. Martínez-González, Gorka Bastarrika
Liver segment 2+3 living donation in liver transplantation for colorectal liver metastases
Svein Dueland, Pål-Dag Line
Can robotic liver resection compensate for weaknesses of the laparoscopic approach?
Daisuke Ban, Yoshiya Ishikawa, Minoru Tanabe

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini


Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.



Original Article

Review Article