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Prof. Henrik Petrowsky: complex hepatobiliary and pancreatic surgery More >>
Prof. Robert S. Warren: come early, stay late and listen More >>
Prof. Silvia Sookoian: knowledge on the natural history and the pathogenesis of non-alcoholic... More >>

Review Article

Appraisal of the current guidelines for management of cholangiocarcinoma—using the Appraisal of Guidelines Research and Evaluation II (AGREE II) Instrument
Paschalis Gavriilidis, Alan Askari, Keith J. Roberts, Robert P. Sutcliffe
Appraisal of the current guidelines for the management of cholangiocarcinoma using AGREE II instrument demonstrated that they are based on relatively low-quality evidence.
Preparing for liver surgery with “Alphabet Soup”: PVE, ALPPS, TAE-PVE, LVD and RL
DaeHee Kim, Joshua Cornman-Homonoff, David C. Madoff
Future liver remnant (FLR) size and function is a critical limiting factor for treatment eligibility and postoperative prognosis when considering major hepatectomy. The article reviews the principles and applications of portal vein embolization (PVE) and the newer hepatic regenerative techniques to improve peri- and postoperative outcomes.

Review Article on Gut Microbiome and Liver Disease

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease
Tiangang Li, John Y. L. Chiang

Original Article on Gut Microbiome and Liver Disease

Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model
Prasant Kumar Jena, Lili Sheng, Yongchun Li, Yui-Jui Yvonne Wan

Original Article

Is there any correlation between liver graft regeneration and recipient’s pretransplant skeletal muscle mass?—a study in extended left lobe graft living-donor liver transplantation
Riccardo Pravisani, Akihiko Soyama, Shinichiro Ono, Umberto Baccarani, Miriam Isola, Mitsuhisa Takatsuki, Masaaki Hidaka, Tomohiko Adachi, Takanobu Hara, Takashi Hamada, Florian Pecquenard, Andrea Risaliti, Susumu Eguchi
This study on living-donor liver transplantation recipients showed that pre-transplant sarcopenia was associated with an impaired early regenerative capacity of the graft. Thus, along with portal circulation and graft quality, even the pre-transplant metabolic status of the recipient is a significant determinant of graft regeneration.


Minimally invasive surgery of malignancies: time to argue the fundamental reasons for this emerging technique
Shengxian Yuan, Weiping Zhou
Sarcopenia, obesity and postoperative outcomes after hepatectomy for hepatocellular carcinoma
Michele Molinari
Is sarcopenic obesity superior to sarcopenia as a predicting indicator in patients with hepatocellular carcinoma following hepatic resection?
Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori
Clinical value and cost-effectiveness of minimally invasive distal pancreatectomy
Andrea Belli, Francesco Izzo, Giulio Belli
Time to take another look at perceived disadvantages of robotic hepatectomy
Yasushi Hasegawa, Hiroyuki Nitta, Takeshi Takahara, Akira Sasaki
Clinical relevance of the relationship between changes in gut microbiota and bile acid metabolism in patients with intrahepatic cholangiocarcinoma
Elisa Herraez, Marta R. Romero, Rocio I. R. Macias, Maria J. Monte, Jose J. G. Marin
Optimizing future remnant liver prior to major hepatectomies: increasing volume while decreasing morbidity and mortality
Hoylan Fernandez, Silvio Nadalin, Giuliano Testa
Is the robot necessary for enhanced recovery after minimally invasive surgery hepatectomy?
Richard S. Hoehn, Samer T. Tohme, David A. Geller
The role of preoperative immune modulating nutrition
Bruce R. Bistrian
Modulation of the gut microbiota represents a new management for non-alcoholic fatty liver disease
Farnush Bakhshimoghaddam, Mohammad Alizadeh
Risk management of hepatocellular carcinoma occurrence after hepatitis C virus eradication—from IFN based era to IFN-free DAA era
Toru Ishikawa
Diabetes is associated with increased risk of hepatocellular carcinoma in non-alcoholic steatohepatitis with cirrhosis—implications for surveillance and future pharmacotherapy
Michael P. Johnston, Janisha Patel, Christopher D. Byrne
Role of image-guided percutaneous thermal ablation in the management of colorectal cancer liver metastases
Nikiforos Vasiniotis Kamarinos, Constantinos T. Sofocleous
Is it time for non-alcoholic fatty liver disease screening in patients with type 2 diabetes mellitus?
Giovanni Targher
Synchronous colorectal liver metastases: timing of resection and patterns of referral
Fiona Hand, Stephen J. Wigmore
Road to identifying endpoint biomarkers in the treatment of nonalcoholic steatohepatitis: are we there yet?
Donghee Kim, Luis Miguel Vazquez-Montesino, Aijaz Ahmed
Is obesity a disease?—the evolving concepts, cancer paradox and association with improved cancer immunotherapy efficacy
Monica Cheng, Richard B. Gunderman

Images in Clinical Medicine

Horrible hepatic portal venous gas
Borui Sun, Chun Zhang

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini


Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.



Original Article