Vol 9, No 2 (April 2020): Hepatobiliary Surgery and Nutrition (Special Focus on Gut Microbiome and Liver Disease)

Review Article

Appraisal of the current guidelines for management of cholangiocarcinoma—using the Appraisal of Guidelines Research and Evaluation II (AGREE II) Instrument
Paschalis Gavriilidis, Alan Askari, Keith J. Roberts, Robert P. Sutcliffe
Appraisal of the current guidelines for the management of cholangiocarcinoma using AGREE II instrument demonstrated that they are based on relatively low-quality evidence.
Preparing for liver surgery with “Alphabet Soup”: PVE, ALPPS, TAE-PVE, LVD and RL
DaeHee Kim, Joshua Cornman-Homonoff, David C. Madoff
Future liver remnant (FLR) size and function is a critical limiting factor for treatment eligibility and postoperative prognosis when considering major hepatectomy. The article reviews the principles and applications of portal vein embolization (PVE) and the newer hepatic regenerative techniques to improve peri- and postoperative outcomes.

Review Article on Gut Microbiome and Liver Disease1

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease
Tiangang Li, John Y. L. Chiang

Original Article on Gut Microbiome and Liver Disease1

Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model
Prasant Kumar Jena, Lili Sheng, Yongchun Li, Yui-Jui Yvonne Wan

Original Article

Is there any correlation between liver graft regeneration and recipient’s pretransplant skeletal muscle mass?—a study in extended left lobe graft living-donor liver transplantation
Riccardo Pravisani, Akihiko Soyama, Shinichiro Ono, Umberto Baccarani, Miriam Isola, Mitsuhisa Takatsuki, Masaaki Hidaka, Tomohiko Adachi, Takanobu Hara, Takashi Hamada, Florian Pecquenard, Andrea Risaliti, Susumu Eguchi
This study on living-donor liver transplantation recipients showed that pre-transplant sarcopenia was associated with an impaired early regenerative capacity of the graft. Thus, along with portal circulation and graft quality, even the pre-transplant metabolic status of the recipient is a significant determinant of graft regeneration.


Minimally invasive surgery of malignancies: time to argue the fundamental reasons for this emerging technique
Shengxian Yuan, Weiping Zhou
Sarcopenia, obesity and postoperative outcomes after hepatectomy for hepatocellular carcinoma
Michele Molinari
Is sarcopenic obesity superior to sarcopenia as a predicting indicator in patients with hepatocellular carcinoma following hepatic resection?
Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori
Clinical value and cost-effectiveness of minimally invasive distal pancreatectomy
Andrea Belli, Francesco Izzo, Giulio Belli
Time to take another look at perceived disadvantages of robotic hepatectomy
Yasushi Hasegawa, Hiroyuki Nitta, Takeshi Takahara, Akira Sasaki
Clinical relevance of the relationship between changes in gut microbiota and bile acid metabolism in patients with intrahepatic cholangiocarcinoma
Elisa Herraez, Marta R. Romero, Rocio I. R. Macias, Maria J. Monte, Jose J. G. Marin
Optimizing future remnant liver prior to major hepatectomies: increasing volume while decreasing morbidity and mortality
Hoylan Fernandez, Silvio Nadalin, Giuliano Testa
Is the robot necessary for enhanced recovery after minimally invasive surgery hepatectomy?
Richard S. Hoehn, Samer T. Tohme, David A. Geller
The role of preoperative immune modulating nutrition
Bruce R. Bistrian
Modulation of the gut microbiota represents a new management for non-alcoholic fatty liver disease
Farnush Bakhshimoghaddam, Mohammad Alizadeh
Risk management of hepatocellular carcinoma occurrence after hepatitis C virus eradication—from IFN based era to IFN-free DAA era
Toru Ishikawa
Diabetes is associated with increased risk of hepatocellular carcinoma in non-alcoholic steatohepatitis with cirrhosis—implications for surveillance and future pharmacotherapy
Michael P. Johnston, Janisha Patel, Christopher D. Byrne
Role of image-guided percutaneous thermal ablation in the management of colorectal cancer liver metastases
Nikiforos Vasiniotis Kamarinos, Constantinos T. Sofocleous
Is it time for non-alcoholic fatty liver disease screening in patients with type 2 diabetes mellitus?
Giovanni Targher
Synchronous colorectal liver metastases: timing of resection and patterns of referral
Fiona Hand, Stephen J. Wigmore
Road to identifying endpoint biomarkers in the treatment of nonalcoholic steatohepatitis: are we there yet?
Donghee Kim, Luis Miguel Vazquez-Montesino, Aijaz Ahmed
Is obesity a disease?—the evolving concepts, cancer paradox and association with improved cancer immunotherapy efficacy
Monica Cheng, Richard B. Gunderman


1. The series “Gut Microbiome and Liver Disease” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding. Yu-Jui Yvonne Wan served as the unpaid Guest Editor for the series.

2. The series “Meet the professor” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.