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Editorial

Signal transducer and activator of transcriptions (STATs)—at the crossroads of obesity-linked non-alcoholic steatohepatitis and hepatocellular carcinoma
Nivida Mishra, Suresh Mishra
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Behavioral healthy nutrition and physical activity counseling in cardiovascular disease prevention: where we are now?
Demosthenes B. Panagiotakos, Matina Kouvari
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Robotic resection for posterosuperior liver lesions: is it really superior to laparoscopic resection?
Andrew K. Y. Fung, Kit-Fai Lee
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Impact of sarcopenia on the progression of nonalcoholic fatty liver disease: a frequently forgotten association
Andrew A. Li, Aijaz Ahmed, Donghee Kim
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Diet quality and nonalcoholic fatty liver disease
Parvin Mirmiran, Farshad Teymoori, Golaleh Asghari, Fereidoun Azizi
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Future is ready for swallowable sensors
Kourosh Kalantar-Zadeh, Stephanie A. Ward
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Paediatric non-alcoholic fatty liver disease: a more complex disease than in the adulthood?
María Teresa Arias-Loste, Paula Iruzubieta, Javier Crespo
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Impact of anatomical resection for hepatocellular carcinoma with microportal invasion (vp1)
Yifei Tan, Wei Zhang, Lunan Yan
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Alcohol use in patients with non-alcoholic fatty liver: a tangled web of causality
Danielle Brandman, Norah A. Terrault
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Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease
Antonio Saviano, Thomas F. Baumert
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The Chengdu system for recurrent hepatocellular carcinoma: A step in the right direction
Simon Erridge, Mikael H. Sodergren
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Going with the gut: probiotics as a novel therapy for hepatocellular carcinoma
Alberto Nicoletti, Maurizio Pompili, Antonio Gasbarrini, Francesca R. Ponziani
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Rising trends in intrahepatic cholangiocarcinoma incidence and mortality: getting at the root cause
Mustafa Raoof, Gagandeep Singh
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Adult-derived human liver stem/progenitor cells as sensors of inflammation: a potential therapy for liver disorders
Soura Mardpour, Amir Ali Hamidieh
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Circadian enhancer profiling in diet-induced obese mice reveals a critical time window for lipid-lowering therapies
Henrik Oster
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Robotic distal pancreatectomy: can results overcome cost-effectiveness prejudices?
Fabrizio Di Benedetto, Roberto Ballarin, Paolo Magistri
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One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade
Aditi Gupta, Sadna Budhu, Taha Merghoub
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What will happen in patients with advanced nonalcoholic fatty liver disease?
Takefumi Kimura, Naoki Tanaka, Eiji Tanaka
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Global standardization of laparoscopic liver resection and challenges for the future
Kenichiro Araki, Norifumi Harimoto, Ken Shirabe
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Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement
Silvia Sookoian, Carlos J. Pirola
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Gut microbiome beats two to zero host genome
Giovanni Cammarota, Lorenza Putignani, Antonio Gasbarrini
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Hepatectomy: more complex operations and improved perioperative outcomes
Laleh Melstrom
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Molecular pathways between obesity, non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC)
Niccolo Petrucciani, Jean Gugenheim
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Bad neighborhoods: apoptotic and necroptotic microenvironments determine liver cancer subtypes
Dieter Adam
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Autophagy elicits a novel and prospect strategy to starve argininedependent tumors
Siyu Lei, Rui Fei, Liancheng Lei
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Adjuvant therapy after radical surgery for hepatocellular carcinoma: still an unmet need
Yasunori Minami, Masatoshi Kudo
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Sorafenib and metformin: to be, or not to be, that is the question
Giulia Orsi, Andrea Casadei-Gardini
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Increasing contribution of non-alcoholic fatty liver disease to hepatocellular carcinoma incidence and mortality in U.S. Medicare
Carrie R. Wong, Joseph K. Lim
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Relative skeletal muscle mass and non-alcoholic fatty liver disease: from association to causation
Hee Yeon Kim, Jong Young Choi, Yong-Moon Park
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Chasing the right path: tips, tricks and challenges of robotic approach to posterior segments
Fabrizio Di Benedetto, Giuseppe Tarantino, Paolo Magistri
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Ramucirumab as a second-line treatment for hepatocellular carcinoma: reaching out further to patients with elevated alpha-fetoprotein
Edoardo G. Giannini, Franco Trevisani
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ALPPS and its further developments in the last decade
Wan Yee Lau
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Commentary

Laparoscopic liver surgery: yesterday, today and tomorrow
Nikolaos Machairas, Georgios C. Sotiropoulos
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Simultaneous resection of primary colorectal cancer and its liver metastases: why not?
Joost Hof, Koert P. de Jong
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Original Article

Neoplastic polyps in gallbladder: a retrospective study to determine risk factors and treatment strategy for gallbladder polyps
Yongliang Sun, Zhiying Yang, Xu Lan, Haidong Tan
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Influence of the body mass index on postoperative outcome and long-term survival after pancreatic resections in patients with underlying malignancy
Philippa Seika, Fritz Klein, Uwe Pelzer, Johann Pratschke, Marcus Bahra, Thomas Malinka
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Development and validation of a nomogram for survival benefit of lymphadenectomy in resected gallbladder cancer
Mingyu Chen, Jian Lin, Jiasheng Cao, Hepan Zhu, Bin Zhang, Angela Wu, Xiujun Cai
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Bilateral proficiency over time leads to reduced donor morbidity in living donor hepatectomy
Viola Huang, Chao-Long Chen, Yu-Hung Lin, Tsan-Shiun Lin, Chih-Che Lin, Shih-Ho Wang, Chee-Chien Yong, Chih-Yi Chen, Yu-Fan Cheng
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Perioperative characteristics and management of liver transplantation for isolated methylmalonic acidemia—the largest experience in China
Yi-Zhou Jiang, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Yu-Le Tan, En-Hui He, Rui-Fang Xu, Liang Zhang, Jun Wang, Xiao-Jie Chen
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Circulating osteopontin per tumor volume as a prognostic biomarker for resectable intrahepatic cholangiocarcinoma
Kai-Qian Zhou, Wei-Feng Liu, Liu-Xiao Yang, Yun-Fan Sun, Jie Hu, Fei-Yu Chen, Cheng Zhou, Xiang-Yu Zhang, Yuan-Fei Peng, Lei Yu, Jian Zhou, Jia Fan, Zheng Wang
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Endogenously increased n-3 PUFA levels in fat-1 transgenic mice do not protect from non-alcoholic steatohepatitis
Marie Liebig, Dirk Dannenberger, Brigitte Vollmar, Kerstin Abshagen
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Clinical validation of scoring systems of postoperative pancreatic fistula after pancreatoduodenectomy: applicability to Eastern cohorts?
Jae Seung Kang, Taesung Park, Youngmin Han, Seungyeon Lee, Jae Ri Kim, Hongbeom Kim, Wooil Kwon, Sun-Whe Kim, Jin Seok Heo, Seong Ho Choi, Dong Wook Choi, Song Cheol Kim, Tae Ho Hong, Dong Sup Yoon, Joon Seong Park, Sang Jae Park, Sung-Sik Han, Sae-Byeol Choi, Joo Seop Kim, Chang-Sup Lim, Jin-Young Jang
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Fasciola hepatica in a country of low incidence: a tricky diagnosis
Stéphanie Perrodin, Laura Walti, Bruno Gottstein, Corina Kim-Fuchs, Daniel Candinas, Vanessa Banz
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Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer
Scott Kizy, Ariella M. Altman, Keith M. Wirth, Schelomo Marmor, Jane Y. C. Hui, Todd M. Tuttle, Emil Lou, Khalid Amin, Jason W. Denbo, Eric H. Jensen
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Comparative long-term outcomes for pancreatic volume change, nutritional status, and incidence of new-onset diabetes between pancreatogastrostomy and pancreatojejunostomy after pancreaticoduodenectomy
Bong Jun Kwak, Ho Joong Choi, Young Kyoung You, Dong Goo Kim, Tae Ho Hong
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Review Article

Current perspectives into the evaluation and management of hepatitis B: a review
Vignan Manne, Eric Gochanour, Kris V. Kowdley
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Hepatobiliary surgeons meet immunologists: the case of colorectal liver metastases patients
Matteo Donadon, Nina Cortese, Federica Marchesi, Matteo Cimino, Alberto Mantovani, Guido Torzilli
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A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy
Prita Daliya, Elizabeth H. Gemmill, Dileep N. Lobo, Simon L. Parsons
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Bidirectional graft-host hematological traffic in liver transplantation
Hemant Sharma, Mauro Tun Abraham, Vivian McAlister
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Techniques for laparoscopic liver parenchymal transection
Tomoaki Yoh, François Cauchy, Olivier Soubrane
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Images in Clinical Medicine

Pancreatic head cancer in a patient with complete agenesis of dorsal pancreas
Alexander E. Julianov, Azize S. Saroglu
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Viewpoint

Alcohol consumption in non-alcoholic fatty liver disease—harmful or beneficial?
Stergios Kechagias, Julia Blomdahl, Mattias Ekstedt
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Alcohol consumption as a cause of cancer: urging for more mechanism study
Feihu Xie, Shi Feng, Yilei Mao
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Tumor progression in two-stage liver resections—is the shorter inter-stage period in ALPPS of benefit to the patient?
Ernesto Sparrelid, Thomas M. van Gulik
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Hepatocellular carcinoma surveillance: an open question
Maurizio Biselli, Francesca Garuti, Andrea Neri
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Difficulty scores in laparoscopic liver surgery—getting closer to a powerful and necessary tool
Ruben Ciria, Maria Dolores Ayllon, Javier Briceño
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Unmet needs in preoperative biliary stenting for patient candidates for pancreaticoduodenectomy: a viewpoint
Salvatore Paiella, Matteo De Pastena, Roberto Salvia
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Assessing the postoperative behaviors of minimally-invasive pancreatoduodenectomy versus open pancreatoduodenectomy
Danjie Jiang, Kun Chen
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Are direct-acting antivirals against hepatitis C virus infection not associated with the recurrence of hepatocellular carcinoma?
Masahiro Ogawa, Tatsuo Kanda, Mitsuhiko Moriyama
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Striving for decreased post-transplant hepatocellular carcinoma recurrence without excluding potentially curable patients: the utility of tumor biology
Russell Evan Rosenblatt, Karim Jarir Halazun
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Liver resection versus chemoembolization for patients with multifocal hepatocellular carcinoma
Victor M. Zaydfudim, Reid B. Adams
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Histologic and molecular features of small well-differentiated pancreatic neuroendocrine tumors associated with the development of liver metastases
Paula Jiménez-Fonseca, Patricia Morales del Burgo, Felipe Alvarez-Manceñido
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Big size is not all, even better!
Roberto Ivan Troisi, Mariano Cesare Giglio, Roberto Montalti
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Is there a place for Ramucirumab after Sorafenib in patients with advanced HCC?
Yeo Jeong So, Sophia Frentzas, Eva Segelov
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Viewpoint: necroptosis influences the type of liver cancer via changes of hepatic microenvironment
Waqar K. Saeed, Dae Won Jun
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The current role of liver surgery in the treatment of colorectal liver metastases
Stefan Heinrich
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Special Issue: Antibodies and Liver Transplantation, Guest-Edited by Prof. Vivian McAlister

The impact of alloantibodies directed against the second donor on long-term outcomes of repeat liver transplantation
Qingyong Xu, Brad Shrum, Steve Leckie, Anton Skaro, Vivian C. McAlister
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Editorial Commentary

Preoperative biliary drainage for resectable or borderline resectable periampullary tumor: what is the best management?
Julie Perinel, Mustapha Adham
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