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Editorial

An updated scoring system for prediction of survival after resection of colorectal liver metastases: addition of KRAS status as an important risk modifier
Evan Jost, Don Major, Elijah Dixon
Radioguided surgery with 68Ga-DOTATATE for patients with neuroendocrine tumors
Valentina Ambrosini, Stefano Fanti
Repeat hepatectomy for recurrent colorectal cancer liver metastases after two-stage hepatectomy—limitations and opportunities
Hop S. Tran Cao, Jean-Nicolas Vauthey
Dissociating nonalcoholic steatohepatitis from hepatocellular carcinoma in obesity
Stergios A. Polyzos, Jannis Kountouras, Antonis Goulas, Eleni Papakonstantinou, Paraskevi Papaioannidou
Hepatocellular carcinoma surveillance: the often-neglected practice
Jennifer Sammon, Korosh Khalili
Possibility of repeat surgery for recurrence following two-stage hepatectomy for colorectal liver metastases: impact on patient outcome
Francesco Ardito
The role of preoperative immune modulating nutrition
Bruce R. Bistrian
Combined portal vein and hepatic vein embolization—finally the platinum procedure of regenerative liver surgery?
Erik Schadde
Is sarcopenic obesity superior to sarcopenia as a predicting indicator in patients with hepatocellular carcinoma following hepatic resection?
Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori
Sarcopenia, obesity and postoperative outcomes after hepatectomy for hepatocellular carcinoma
Michele Molinari
Risk management of hepatocellular carcinoma occurrence after hepatitis C virus eradication—from IFN based era to IFN-free DAA era
Toru Ishikawa
Road to identifying endpoint biomarkers in the treatment of nonalcoholic steatohepatitis: are we there yet?
Donghee Kim, Luis Miguel Vazquez-Montesino, Aijaz Ahmed
Synchronous colorectal liver metastases: timing of resection and patterns of referral
Fiona Hand, Stephen J. Wigmore
Time to take another look at perceived disadvantages of robotic hepatectomy
Yasushi Hasegawa, Hiroyuki Nitta, Takeshi Takahara, Akira Sasaki
Diabetes is associated with increased risk of hepatocellular carcinoma in non-alcoholic steatohepatitis with cirrhosis—implications for surveillance and future pharmacotherapy
Michael P. Johnston, Janisha Patel, Christopher D. Byrne
Clinical relevance of the relationship between changes in gut microbiota and bile acid metabolism in patients with intrahepatic cholangiocarcinoma
Elisa Herraez, Marta R. Romero, Rocio I. R. Macias, Maria J. Monte, Jose J. G. Marin
Focus on immune-related adverse events (irAEs) in immunotherapy of hepatobiliary malignancies
Lei Zhang, Haitao Zhao
Role of image-guided percutaneous thermal ablation in the management of colorectal cancer liver metastases
Nikiforos Vasiniotis Kamarinos, Constantinos T. Sofocleous
Liver transplantation for colorectal metastasis: a stepwise approach
Axel Andres, Christian Toso
Clinical value and cost-effectiveness of minimally invasive distal pancreatectomy
Andrea Belli, Francesco Izzo, Giulio Belli
Editorial on “Role of thermal ablation in the management of colorectal liver metastasis”
Antonio Giorgio, Pietro Gatti, Massimo De Luca, Paolo Matteucci, Valentina Giorgio
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)—pushing the envelope in modulation of future liver remnant before major hepatectomy
Albert C. Y. Chan, Chung Mau Lo
Is it time for non-alcoholic fatty liver disease screening in patients with type 2 diabetes mellitus?
Giovanni Targher
Is the robot necessary for enhanced recovery after minimally invasive surgery hepatectomy?
Richard S. Hoehn, Samer T. Tohme, David A. Geller
Refining selection criteria to further increase survival benefit in liver transplantation for unresectable colorectal liver metastases
Matteo Serenari, Matteo Ravaioli
Clinical implications of the dual blockade of the PD-1/PD-L1 and vascular endothelial growth factor axes in the treatment of hepatocellular carcinoma
Naoshi Nishida
Immunotherapy in hepatobiliary tumors: search for the missing pieces of the puzzle
Matteo Donadon, Federica Marchesi, Lorenza Rimassa, Guido Torzilli
An international expert consensus of management of recurrent hepatocellular carcinoma: a viewpoint
Kuniya Tanaka, Yuki Takahashi, Tetsuji Wakabayashi
Modulation of the gut microbiota represents a new management for non-alcoholic fatty liver disease
Farnush Bakhshimoghaddam, Mohammad Alizadeh
Vessels encapsulating tumor clusters in hepatocellular carcinoma: a unique and valuable pathological imaging
Yo-ichi Yamashita, Hideo Baba
PNPLA3 and nonalcoholic fatty liver disease: towards personalized medicine for fatty liver
Liyun Yuan, Norah A. Terrrault
Faecal microbiota transplantation as an elixir of youth
Craig Haifer, Sudarshan Paramsothy, Rupert W. Leong
Nutritional support treatment for perioperative patients in hepatobiliary surgery
Shuifang Jin, Ronglin Jiang, Xi Xing, Weibin Ma
Laparoscopic liver resections at the gates of 2020: a stand-alone field of hepatobiliary surgery
Federica Cipriani, Francesca Ratti, Luca Aldrighetti
Prudent use of a left hepatic graft in adult-to-adult living donor liver transplantation: aiming for further securing donors’ safety
Hideaki Uchiyama
Diabetes and hepatocellular carcinoma risks in patients with nonalcoholic steatohepatitis related cirrhosis
Chien-Hsieh Chiang, Kuo-Chin Huang
Optimizing future remnant liver prior to major hepatectomies: Increasing volume while decreasing morbidity and mortality
Hoylan Fernandez, Silvio Nadalin, Giuliano Testa
The future of adjuvant therapy in ampullary cancer: should we offer it to our patients?
Sri Harsha Tella, Amit Mahipal
Risk stratification of HCC occurrence after HCV eradication: a complicate plot of risk factors related and unrelated to the previous viral disease
Valentina Cossiga, Maria Guarino, Filomena Morisco, Nicola Caporaso
Liver segment 2+3 living donation in liver transplantation for colorectal liver metastases
Svein Dueland, Pål-Dag Line
Gut microbiota and hepatocellular carcinoma
Panzhi Wang, Kun Chen
Bilateral proficiency over time leads to reduced donor morbidity in living donor hepatectomy
Jan P. Lerut
Could hepatic ablation promote development of colon cancer hepatic metastases?
Crystal Kyaw, Joyce Wong
Nonalcoholic fatty liver disease in type 2 diabetes: awareness is the first step toward change
Fernando Bril
Non-alcoholic fatty liver disease (NAFLD) diagnosis and management—differentiating the essential from the ancillary and the present from the future
Amedeo Lonardo, Simonetta Lugari, Fabio Nascimbeni
Probiotics and synbiotics targeting the intestinal microbiome attenuate non-alcoholic fatty liver disease
Luis Vitetta, Jeremy D. Henson
Can robotic liver resection compensate for weaknesses of the laparoscopic approach?
Daisuke Ban, Yoshiya Ishikawa, Minoru Tanabe
Evaluating the application of next generation sequencing techniques in endoscopic retrograde cholangiopancreatography (ERCP) to improve diagnostic accuracy in patients with malignant biliary strictures
Tan To Cheung
Locally advanced pancreatic cancer: staging, operability, and the importance of multimodality therapy
Rebecca Y. Kim, Douglas B. Evans, Kathleen K. Christians
Dual angiogenesis and PD-1 blockade in hepatocellular carcinoma
Julien Calderaro
The rapidly expanding role of thermal ablation in the treatment of colorectal liver metastases
Martijn R. Meijerink, M. Petrousjka van den Tol, Robbert S. Puijk
Mediterranean diet as the ideal model for preventing non-alcoholic fatty liver disease (NAFLD)
Miguel A. Martínez-González, Gorka Bastarrika
Expanding treatment strategies for hepatocellular carcinoma patients: postoperative adjuvant transarterial chemoembolization
Rodolfo Sacco, Antonio Facciorusso
Ampullary adenocarcinoma: the current state of adjuvant therapies
Charles C. Vining, Darryl Schuitevoerder, Kiran K. Turaga
Hepatocellular carcinoma and liver transplant: beyond the Milan criteria and the risk of “short-blanket” syndrome
Stefano Gitto, Stefano Di Sandro, Paolo Magistri, Pietro Andreone, Fabrizio Di Benedetto

Original Article

Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer
Scott Kizy, Ariella M. Altman, Keith M. Wirth, Schelomo Marmor, Jane Y. C. Hui, Todd M. Tuttle, Emil Lou, Khalid Amin, Jason W. Denbo, Eric H. Jensen
Comparative long-term outcomes for pancreatic volume change, nutritional status, and incidence of new-onset diabetes between pancreatogastrostomy and pancreatojejunostomy after pancreaticoduodenectomy
Bong Jun Kwak, Ho Joong Choi, Young Kyoung You, Dong Goo Kim, Tae Ho Hong
Retrospective analysis of 45 cases of localized retroperitoneal Castleman disease from a single center
Jian-Qiang Tang, He-Kai Chen, Xin Wang, Ming-Yue Wang, Yan Xiong, He Wang, Yin-Mo Yang
Radiographic characteristics of neuroendocrine liver metastases do not predict clinical outcomes following liver resection
Emily A. Armstrong, Eliza W. Beal, Manisha Shah, Bhavana Konda, Sherif Abdel-Misih, Aslam Ejaz, Mary E. Dillhoff, Timothy M. Pawlik, Jordan M. Cloyd
Prospective study to evaluate the prognostic value of different nutritional assessment scores in liver surgery: NURIMAS Liver (DRKS00006340)
Pascal Probst, Juri Fuchs, Michael R. Schön, Georgios Polychronidis, Christos Stravodimos, Arianeb Mehrabi, Markus K. Diener, Philipp Knebel, Markus W. Büchler, Katrin Hoffmann
Immunotherapy utilization for hepatobiliary cancer in the United States: disparities among patients with different socioeconomic status
Kota Sahara, S. Ayesha Farooq, Diamantis I. Tsilimigras, Katiuscha Merath, Anghela Z. Paredes, Lu Wu, Rittal Mehta, J. Madison Hyer, Itaru Endo, Timothy M. Pawlik
Adjuvant chemotherapy for intrahepatic cholangiocarcinoma: approaching clinical practice consensus?
Ariella M. Altman, Scott Kizy, Schelomo Marmor, Jane Y. C. Hui, Todd M. Tuttle, Eric H. Jensen, Jason W. Denbo
Radioembolization for neuroendocrine liver metastases is safe and effective prior to major hepatic resection
Florian Bösch, Harun Ilhan, Vanessa Pfahler, Michael Thomas, Thomas Knösel, Valentin Eibl, Sebastian Pratschke, Peter Bartenstein, Max Seidensticker, Christoph J. Auernhammer, Christine Spitzweg, Markus O. Guba, Jens Werner, Martin K. Angele
Limited potential of resolvin D1 in treatment of cholestatic liver fibrosis
Kerstin Abshagen, Alexander Hartmann, Laura Grüner, Marie Liebig, Brigitte Vollmar
Severity of early allograft dysfunction following donation after circulatory death liver transplantation: a multicentre study
Kun Wang, Di Lu, Yuhui Liu, Wangyao Li, Li Zhuang, Zhenyu Ma, Qinfen Xie, Binhua Pan, Yichao Wu, Junli Chen, Lidan Lin, Xiaowen Feng, Qiang Wei, Xuyong Wei, Haiyang Xie, Zhengxin Wang, Shusen Zheng, Xiao Xu
Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients
Shuo Wang, Huasheng Shi, Tao Liu, Manjiang Li, Sanshun Zhou, Xuan Qiu, Zusen Wang, Weiyu Hu, Weidong Guo, Xiaoqian Chen, Honglin Guo, Xiaoliang Shi, Junping Shi, Yunjin Zang, Jingyu Cao, Liqun Wu
A new classification for hepatocellular carcinoma with hepatic vein tumor thrombus
Zhen-Hua Chen, Kang Wang, Xiu-Ping Zhang, Jing-Kai Feng, Zong-Tao Chai, Wei-Xing Guo, Jie Shi, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model
Prasant Kumar Jena, Lili Sheng, Yongchun Li, Yui-Jui Yvonne Wan
Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma—a cost-effectiveness analysis
Kevin K. W. Chu, Albert C. Y. Chan, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Kenneth S. H. Chok, Tan To Cheung, Chung Mau Lo
How should liver hypertrophy be stimulated? A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and portal vein embolization (PVE) with rescue possibility
Ernesto Sparrelid, Kristina Hasselgren, Bård Ingvar Røsok, Peter Nørgaard Larsen, Nicolai Aagaard Schultz, Ulrik Carling, Eva Fallentin, Stefan Gilg, Per Sandström, Gert Lindell, Bergthor Björnsson
The impact of standardized methods of hepatic vein reconstruction with an external iliac vein graft
Fumihiro Terasaki, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Yasuyuki Fukami, Takamasa Takahashi, Masahito Uji
Is there any correlation between liver graft regeneration and recipient’s pretransplant skeletal muscle mass?—A study in extended left lobe graft living-donor liver transplantation
Riccardo Pravisani, Akihiko Soyama, Shinichiro Ono, Umberto Baccarani, Miriam Isola, Mitsuhisa Takatsuki, Masaaki Hidaka, Tomohiko Adachi, Takanobu Hara, Takashi Hamada, Florian Pecquenard, Andrea Risaliti, Susumu Eguchi
New-onset diabetes after adult liver transplantation in the Korean Organ Transplantation Registry (KOTRY) study
Jong Man Kim, Shin Hwang, Kwang-Woong Lee, Jae-Geun Lee, Je Ho Ryu, Bong-Wan Kim, Dong Lak Choi, Young Kyoung You, Dong-Sik Kim, Yang Won Nah, Koo Jeong Kang, Jai Young Cho, Geun Hong, In Seok Choi, Hee Chul Yu, Dongho Choi, Myoung Soo Kim, The Korean Organ Transplantation Registry Study Group
The benefit of curative liver resection with a selective bile duct preserving approach for hepatocellular carcinoma with macroscopic bile duct tumor thrombus
Anon Chotirosniramit, Akkaphod Liwattanakun, Sunhawit Junrungsee, Wasana Ko-iam, Trichak Sandhu, Worakitti Lapisatepun

Review Article

Use of imaging as staging and surgical planning for pancreatic surgery
Andrew Hieu Nguyen, Laleh G. Melstrom
Surgical approach to synchronous colorectal liver metastases: staged, combined, or reverse strategy
Heather A. Lillemoe, Jean-Nicolas Vauthey
Current state of the art imaging approaches for colorectal liver metastasis
Bita Hazhirkarzar, Pegah Khoshpouri, Mohammadreza Shaghaghi, Mounes Aliyari Ghasabeh, Timothy M. Pawlik, Ihab R. Kamel
Role of thermal ablation in the management of colorectal liver metastasis
Hideo Takahashi, Eren Berber
Renewed considerations on the utility (or the futility) of hepatic resections for breast cancer liver metastases
Gian Luca Grazi
The role of associating liver partition and portal vein ligation for staged hepatectomy in the management of patients with colorectal liver metastasis
Juan Glinka, Victoria Ardiles, Juan Pekolj, Eduardo de Santibañes, Martin de Santibañes
Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease
Tiangang Li, John Y. L. Chiang
Biliary complications after liver transplantation: current perspectives and future strategies
Bianca Magro, Matteo Tacelli, Alessandra Mazzola, Filomena Conti, Ciro Celsa
Hepatocellular carcinoma in non-alcoholic fatty liver disease—a review of an emerging challenge facing clinicians
Daniel Geh, Derek M. Manas, Helen L. Reeves
Appraisal of the current guidelines for management of cholangiocarcinoma—using the Appraisal of Guidelines Research and Evaluation II (AGREE II) Instrument
Paschalis Gavriilidis, Alan Askari, Keith J. Roberts, Robert P. Sutcliffe
Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores
Thinzar M. Lwin, Robert M. Hoffman, Michael Bouvet
Preparing for liver surgery with “Alphabet Soup”: PVE, ALPPS, TAE-PVE, LVD and RL
DaeHee Kim, Joshua Cornman-Homonoff, David C. Madoff
Impact and clinical usefulness of genetic data in the surgical management of colorectal cancer liver metastasis
Georgios Antonios Margonis, Martin E. Kreis, Jaeyun Jane Wang, Carsten Kamphues, Christopher L. Wolfgang, Matthew J. Weiss

Letter to the Editor

Prevention of bile spillage during cholecystectomy: current evidences and considerations
Maurizio Zizzo, Lorenzo Manzini, Magda Zanelli, Loredana De Marco, Carolina Castro Ruiz, Antonio Manenti, Valerio Annessi

Images in Clinical Medicine

Laparoscopic cholecystectomy for double gallbladder
Qingbo Feng, Xiaobing Wu