Evaluating the application of next generation sequencing techniques in endoscopic retrograde cholangiopancreatography (ERCP) to improve diagnostic accuracy in patients with malignant biliary strictures

Tan To Cheung

Abstract

Malignant biliary obstruction is a sinister condition that require radical treatment in order to provide the hope of a cure. Apart from complex surgery, the major clinical challenge remains the difficulty in making a conclusive diagnosis (1). There is a long list of differential diagnosis for obstruction of the bile duct including benign condition like primary sclerosing cholangitis, iatrogenic injury, infection and IgG 4 related conditions to malignant condition like carcinoma involving the whole course of bile duct, pancreatic carcinoma and adenocarcinoma in the periampullary regions (2-5).