Article Abstract

Cholangiocarcinoma: increasing burden of classifications

Authors: Vincenzo Cardinale, Maria Consiglia Bragazzi, Guido Carpino, Alessia Torrice, Alice Fraveto, Raffaele Gentile, Vincenzo Pasqualino, Fabio Melandro, Camilla Aliberti, Carlo Bastianelli, Roberto Brunelli, Pasquale Bartolomeo Berloco, Eugenio Gaudio, Domenico Alvaro

Abstract

holangiocarcinoma (CCA) is a very heterogeneous cancer from any point of view, including epidemiology, risk factors, morphology, pathology, molecular pathology, modalities of growth and clinical features. Given this heterogeneity, a uniform classification respecting the epidemiologic, pathologic and clinical needs is currently lacking. In this manuscript we discussed the different proposed classifications of CCA in relation with recent advances in pathophysiology and biology of this cancer.