Enteric dysbiosis, gut barrier and liver disease

By employing the powerful animal model—Germ free mice and the development of the sequencing technology, gut microbiota nowadays has been recognized as a key pathophysiologic modulator for many diseases development, including liver injury progression. Intestinal microbial composition alteration, as well as functional disruption due to hepatotoxic agents challenge such as alcohol, fat or bile acids is recognized as the initial event during liver damage occurrence. Such dysbiotic status is complicated and is not fully understood yet.