Vol 10, No 4 (August 05, 2021): Hepatobiliary Surgery and Nutrition

The Story Behind the Cover Picture

The bronze liver of Piacenza
Thomas M. van Gulik

Original Article

Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy
Xiaobo Yang, Haifeng Xu, Bangyou Zuo, Xu Yang, Jin Bian, Junyu Long, Dongxu Wang, Junwei Zhang, Cong Ning, Yanyu Wang, Ziyu Xun, Yunchao Wang, Xin Lu, Yilei Mao, Xinting Sang, Haitao Zhao
1. Stereotactic therapy can successfully convert patients with hepatocellular carcinoma of CNLC stage IIIB to resectable status;
2. Systemic therapy combined with locoregional therapy at early time tended to prolong tumor-free survival time;
3. The treatment regimen was safe with no serious AEs occurred, and worth promoting.
A comparative study of pancreas transplantation between type 1 and 2 diabetes mellitus
Bor-Shiuan Shyr, Bor-Uei Shyr, Shih-Chin Chen, Che-Chuan Loong, Yi-Ming Shyr, Shin-E Wang
Type 2 DM is not inferior to Type 1 DM after pancreas transplantation in terms of surgical risks, immunological and endocrine outcomes, and graft survival rates. Pancreas transplantation could be an effective option to treat selected uremic Type 2 DM patients without significant insulin resistance.
High HbA1c is a risk factor for complications after hepatectomy and influences for hepatocellular carcinoma without HBV and HCV infection
Shingo Shimada, Toshiya Kamiyama, Tatsuya Orimo, Akihisa Nagatsu, Hirofumi Kamachi, Akinobu Taketomi
Although high HbA1c was not significant prognostic factor in HCC patients with viral hepatitis, it was significant prognostic factor in NBNC patients. This study also revealed that high HbA1c may also be a risk factor for morbidities after hepatectomy.
A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection
Seogsong Jeong, Guijuan Luo, Qiang Gao, Jing Chen, Xiaolong Liu, Liangqing Dong, Yongjie Zhang, Feng Shen, Qingbao Cheng, Chengjun Sui, Jingfeng Liu, Hongyang Wang, Qiang Xia, Lei Chen
This multicenter study demonstrated that the combined Cox and logistic ranking system allows accurate estimation on the risk of recurrence for patients with intrahepatic cholangiocarcinoma after resection. The derived model may be useful in stratifying individuals who sole resection of the tumor may not be curative.
The potential use of extended criteria donors and eligible recipients in liver transplantation for unresectable colorectal liver metastases in Central Sweden
Christina Villard, Joakim Westman, Jonas Frank, Oystein Jynge, Ernesto Sparrelid, Carl Jorns
With current selection criteria a small subset of patients with unresectable CRLM could be accepted for LT. The use of extended criteria donors could increase today’s donor pool by 6-18%. This donor pool is sufficient and displays an acceptable risk-benefit ratio for patients with unresectable CRLM.
Use of donor-specific red blood cell transfusions for patients undergoing liver transplantation during the COVID-19 pandemic
Tao Lv, Xi Xu, Jiulin Song, Yifei Tan, Li Jiang, Jian Yang, Diao He, Lingxiang Kong, Weiyi Zhang, Panyu Chen, Qiwen Xiang, Tao Zhu, Hong Wu, Tianfu Wen, Jiayin Yang
This is the first prospective clinical trial that evaluated the effect of DRBCT on DDLT, and our results suggested that DRBCT is a safe and effective procedure to lower the need for blood. Moreover, it reduced the level of postoperative AST to a certain extent.
Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer, a comparison with GEMOX regimen
Xu-Ya Cui, Xue-Chuan Li, Jiu-Jie Cui, Xiang-Song Wu, Lu Zou, Xiao-Ling Song, Tai Ren, Yi-Di Zhu, Huai-Feng Li, Yang Yang, Ke Liu, Xu-Sheng Han, Zi-Yao Jia, Wen-Guang Wu, Xu-An Wang, Wei Gong, Li-Wei Wang, Mao-Lan Li, Ying-Bin Liu
Chemotherapy is the major palliative treatment for advanced GBC. In this study, 44 patients with unresectable locally advanced or metastatic GBC were involved, and the mFOLFIRINOX regimen may improve the PFS and OS compared to the GEMOX regimen, while both regimens have similar rates of adverse events.

Editorial

Surgical decision-making: can patients benefit?
Ming Liu, Baocai Xing
Trends in the use of adjuvant therapy for resected intrahepatic cholangiocarcinoma: getting ahead of the data
Jordan M. Cloyd, Timothy M. Pawlik
Glucagon-like peptide-1 receptor agonists for treatment of nonalcoholic steatohepatitis: new insights from subcutaneous semaglutide
Alessandro Mantovani, Giovanni Targher
Lack of response to immunotherapy in non-alcoholic steatohepatitis related hepatocellular carcinoma
Masatoshi Kudo
Liver metastases “siphon” off immunotherapy response
Nina Cortese, Federica Marchesi
Whole grain intake and pancreatic cancer risk
Glenn A. Gaesser
Perioperative immunotherapy for pancreatic cancer is on its way
Christoph Springfeld, Peter Bailey, Thilo Hackert, John P. Neoptolemos
Classification of hepatic venous tumor thrombus in hepatocellular carcinoma: should it describe tumor status or predict patient survival?
Norihiro Kokudo, Wei Tang, Takashi Kokudo
Semaglutide for nonalcoholic steatohepatitis: closer to a solution?
Christina Liava, Emmanouil Sinakos
Improvement and development in anatomical hepatectomy for hepatocellular carcinoma
Takeshi Takamoto
Genome-wide analysis of hepatitis B virus integration in hepatocellular carcinoma: Insights next generation sequencing
Yutaka Midorikawa, Kenji Tatsuno, Mitsuhiko Moriyama
Prognostic risk scores for liver transplantation: game changers or statistical artworks?
Marco P. A. W. Claasen, Tommy Ivanics, Annabel Gravely, Gonzalo Sapisochin