Vol 10, No 3 (June 2021): Hepatobiliary Surgery and Nutrition

Original Article

Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma—a cost-effectiveness analysis
Kevin K. W. Chu, Albert C. Y. Chan, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Kenneth S. H. Chok, Tan To Cheung, Chung Mau Lo
Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP ≥400ng/ml or bilobar disease. Its routine use in preoperative workup for all HCC patients is not recommended because unilobar disease with AFP <400ng/ml has good negative predictive value.
Liver transplantation: would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?
Ka Wing Ma, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Wong Hoi She, Tan To Cheung, Wing Chiu Dai, James Yan Yue Fung, Chung Mau Lo
Although PVTT in HCC has been considered a sinister feature and hence a contraindication for LT for the sake of better liver graft utility, this study demonstrates that LT can confer much better oncological outcomes compared to hepatectomy in the context of HCC with PVTT.
A simple scoring system to estimate perioperative mortality following liver resection for primary liver malignancy—the Hepatectomy Risk Score (HeRS)
Dimitrios Moris, Brian I. Shaw, Cecilia Ong, Ashton Connor, Mariya L. Samoylova, Samuel J. Kesseli, Nader Abraham, Jared Gloria, Robin Schmitz, Zachary W. Fitch, Bryan M. Clary, Andrew S. Barbas
The Hepatectomy Risk Score (HeRS) incorporates the extent of resection and a MELD-Na score category to predict 30-day mortality after resection of primary liver malignancy. More complicated models offer better performance but at the expense of being more difficult to integrate into clinical practice.
The beneficial impacts of splanchnic vasoactive agents on hepatic functional recovery in massive hepatectomy porcine model
Hye-Sung Jo, Jae Hyun Han, Yoon Young Choi, Jin-I Seok, Young-In Yoon, Dong-Sik Kim
Excessive postoperative portal pressure, a major cause of post-hepatectomy liver failure and small-for-size syndrome after partial liver transplantation, is a difficult problem to be solved. Pharmacologic portal modulation with splanchnic vasoactive agents could optimize liver regeneration and attenuate liver injury after massive hepatectomy.

Review Article

Liver tissue microbiota in nonalcoholic liver disease: a change in the paradigm of host-bacterial interactions
Silvia Sookoian, Carlos J. Pirola
We highlight the evidence on the role of non-intestinal microbiotas in liver diseases with emphasis on liver tissue bacterial DNA in the biology of NAFLD and NASH. Also, we provide evidence of metagenomic findings that can be leveraged to discover novel therapeutic targets.
Optimization of the future remnant liver: review of the current strategies in Europe
Riccardo Memeo, Maria Conticchio, Emmanuel Deshayes, Silvio Nadalin, Astrid Herrero, Boris Guiu, Fabrizio Panaro


Long-term health-related quality of life of living liver donors: what should the transplant team know?
Kohei Ogawa, Katsunori Sakamoto, Yasutsugu Takada
Refining the surgical playbook for treating colorectal cancer liver metastases
Luis I. Ruffolo, Roberto Hernandez-Alejandro, Koji Tomiyama
Expert consensus on magnetic recanalization technique for biliary anastomotic strictures after liver transplantation
Yu Li, Nan Zhang, Yi Lv, Scientific Committee of the Third International Conference of Magnetic Surgery
The role of the robot-assisted procedure during total pancreatectomy: a viewpoint
Matteo De Pastena, Alessandro Esposito, Roberto Salvia
Are probiotics effective in reversing non-alcoholic steatohepatitis?
Ludovico Abenavoli, Luigi Boccuto, Emidio Scarpellini
Management of neuroendocrine liver metastasis: Searching for new prognostic factor and appraising repeat hepatectomy
Junichi Arita, Sho Kiritani, Kiyoshi Hasegawa
Interpatient heterogeneity in hepatic microvascular blood flow during vascular inflow occlusion (Pringle manoeuvre)
Eric Felli, Edoardo Maria Muttillo, Emanuele Felli
Can endoscopic therapy help surgeons to manage post-hepatectomy bile leaks?
Massimiliano Mutignani, Lorenzo Dioscoridi


1. The series “French Editorial from the ACHBPT” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.

2. The series “Images in Clinical Medicine” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.