@article{HBSN24760,
author = {Kai-Qian Zhou and Wei-Feng Liu and Liu-Xiao Yang and Yun-Fan Sun and Jie Hu and Fei-Yu Chen and Cheng Zhou and Xiang-Yu Zhang and Yuan-Fei Peng and Lei Yu and Jian Zhou and Jia Fan and Zheng Wang},
title = {Circulating osteopontin per tumor volume as a prognostic biomarker for resectable intrahepatic cholangiocarcinoma},
journal = {Hepatobiliary Surgery and Nutrition},
volume = {8},
number = {6},
year = {2019},
keywords = {},
abstract = {Background: The role of osteopontin (OPN) in intrahepatic cholangiocarcinoma (ICC) remains controversial. This study aimed to explore the prognostic value of OPN in patients with ICC undergoing curative resection.
Methods: Patients undergoing curative resection from 2005 to 2016 were identified for inclusion in this retrospective study. The expression level of OPN in tumors was measured in each of the 228 patients by immunohistochemistry. Circulating OPN in serum was tested in 124 patients by ELISA. Tumor volume was calculated according to preoperative imaging or operation record. Proliferation assay, wound healing assay, and invasion assay were performed to investigate the biological function.
Results: Low expression of OPN in tissue was associated with lymph node metastasis (P=0.009) and shorter overall survival (OS) (P=0.001). A low level of circulating OPN/volume was associated with multiple tumors (P},
issn = {2304-389X}, url = {https://hbsn.amegroups.org/article/view/24760}
}