TY - JOUR AU - Zhou, Cheng AU - Peng, Yuanfei AU - Zhou, Kaiqian AU - Zhang, Lan AU - Zhang, Xiangyu AU - Yu, Lei AU - Hu, Jie AU - Chen, Feiyu AU - Qiu, Shuangjian AU - Zhou, Jian AU - Fan, Jia AU - Ren, Zhenggang AU - Wang, Zheng PY - 2018 TI - Surgical resection plus radiofrequency ablation for the treatment of multifocal hepatocellular carcinoma JF - Hepatobiliary Surgery and Nutrition; Vol 8, No 1 (February 01, 2019): Hepatobiliary Surgery and Nutrition (Special Focus on Antibodies and Liver Transplantation: Part 1) Y2 - 2018 KW - N2 - Background: To compare the efficacy and safety of surgical resection plus radiofrequency ablation (SR-RFA) with transarterial chemoembolization (TACE) in patients with multifocal hepatocellular carcinoma (HCC) beyond the Milan criteria. Methods: From 2009 to 2015, a total of 469 consecutive patients with multifocal HCC beyond the Milan criteria (≤5 nodules) treated with SR-RFA (n=59) or TACE (n=410) were analyzed. Their overall survival (OS) rate was compared through propensity score matching (PSM) analysis at a ratio of 1:2, and 141 patients were identified (SR-RFA, n=47; TACE, n=94). Subgroup analysis was conducted according to factors associated with treatment options. Results: Before PSM, the 1-, 2- and 3-year OS rates were 81.5%, 68.3% and 64.3% in the SR-RFA group and 58.7%, 35.5% and 24.4% in the TACE group, respectively (all P Conclusions: SR-RFA provides better a long-term survival rate than TACE for patients with multifocal HCC beyond the Milan criteria. SR-RFA may serve as an alternative treatment for patients with multifocal HCC in a selected patient population. UR - https://hbsn.amegroups.org/article/view/22839