%0 Journal Article %T Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma %A Li, Zhen-Li %A Han, Jun %A Liu, Kai %A Xing, Hao %A Wu, Han %A Lau, Wan Yee %A Pawlik, Timothy M. %A Li, Chao %A Wang, Ming-Da %A Yu, Jiong-Jie %A Wu, Meng-Chao %A Shen, Feng %A Yang, Tian %J Hepatobiliary Surgery and Nutrition %D 2018 %B 2018 %9 %! Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma %K %X Background: Family history is a risk factor for the development of hepatocellular carcinoma (HCC). The aim of the current study was to investigate the association between family history of HCC and long-term oncologic prognosis among patients undergoing curative liver resection for hepatitis B virus (HBV)-related HCC. Methods: Patients who underwent curative liver resection of HBV-related HCC between 2003 and 2013 were consecutively enrolled. Family history was defined as a self-reported history of HCC in a first-degree relative. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare overall survival (OS) and recurrence-free survival (RFS) among patients with and without a family history. Results: Among 1,112 patients, 183 (16.5%) patients had a family history of HCC. Using PSM, 179 pairs of patients with and without a family history were created that had no differences in the baseline characteristics and operative variables. On matched analysis, family history was associated with decreased OS and RFS after curative-intent resection of HBV-related HCC in the propensity matching cohort (P=0.042 and 0.006, respectively). On multivariable Cox-regression analyses, a family history of HCC was associated with decreased OS (HR: 1.574; 95% CI: 1.171–2.116; P=0.003) and RFS (HR: 1.534; 95% CI: 1.176–2.002, P=0.002) after adjusting for other prognostic risk factors. Conclusions: Family history was associated with decreased OS and RFS rates among patients undergoing curative liver resection of HBV-related HCC. %U https://hbsn.amegroups.org/article/view/22833 %V 8 %N 2 %P 88-100 %@ 2304-389X