@article{HBSN22833,
author = {Zhen-Li Li and Jun Han and Kai Liu and Hao Xing and Han Wu and Wan Yee Lau and Timothy M. Pawlik and Chao Li and Ming-Da Wang and Jiong-Jie Yu and Meng-Chao Wu and Feng Shen and Tian Yang},
title = {Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma},
journal = {Hepatobiliary Surgery and Nutrition},
volume = {8},
number = {2},
year = {2018},
keywords = {},
abstract = {Background: Family history is a risk factor for the development of hepatocellular carcinoma (HCC). The aim of the current study was to investigate the association between family history of HCC and long-term oncologic prognosis among patients undergoing curative liver resection for hepatitis B virus (HBV)-related HCC.
Methods: Patients who underwent curative liver resection of HBV-related HCC between 2003 and 2013 were consecutively enrolled. Family history was defined as a self-reported history of HCC in a first-degree relative. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare overall survival (OS) and recurrence-free survival (RFS) among patients with and without a family history.
Results: Among 1,112 patients, 183 (16.5%) patients had a family history of HCC. Using PSM, 179 pairs of patients with and without a family history were created that had no differences in the baseline characteristics and operative variables. On matched analysis, family history was associated with decreased OS and RFS after curative-intent resection of HBV-related HCC in the propensity matching cohort (P=0.042 and 0.006, respectively). On multivariable Cox-regression analyses, a family history of HCC was associated with decreased OS (HR: 1.574; 95% CI: 1.171–2.116; P=0.003) and RFS (HR: 1.534; 95% CI: 1.176–2.002, P=0.002) after adjusting for other prognostic risk factors.
Conclusions: Family history was associated with decreased OS and RFS rates among patients undergoing curative liver resection of HBV-related HCC.},
issn = {2304-389X}, url = {https://hbsn.amegroups.org/article/view/22833}
}