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Bone morphogenetic protein-9/activin-like kinase 1 axis a new target for hepatic regeneration and fibrosis treatment in liver injury

  
@article{HBSN17472,
	author = {Montserrat Marí and Albert Morales},
	title = {Bone morphogenetic protein-9/activin-like kinase 1 axis a new  target for hepatic regeneration and fibrosis treatment in liver injury},
	journal = {Hepatobiliary Surgery and Nutrition},
	volume = {6},
	number = {6},
	year = {2017},
	keywords = {},
	abstract = {Bone morphogenetic protein-9 (BMP-9), a member of the transforming growth factor (TGF)-β family of cytokines, is preferentially expressed in the liver from where is secreted into the blood (1-3). BMP-9 and BMP-10 are high-affinity ligands for the type I receptor activin-like kinase 1 (ALK1), whose participation in liver fibrosis has been previously suggested, and activin type II receptor A (ActRIIA) a BMP type II receptor with undefined role in liver biology. Although BMP-9 promotes epithelial to mesenchymal transition in hepatocellular carcinoma (HCC) cells, correlating with HCC aggressiveness in patients, and the BMP-9/ALK1 signaling has been related to liver pathologies, little was known about BMP-9 specific functions in liver cells and, particularly, after hepatic injury.},
	issn = {2304-389X},	url = {http://hbsn.amegroups.com/article/view/17472}
}