TY - JOUR AU - Wan, Shaogui AU - Civan, Jesse AU - Rossi, Simona AU - Yang, Hushan PY - 2012 TI - Profiling HBV integrations in hepatocellular carcinoma JF - Hepatobiliary Surgery and Nutrition; Vol 2, No 2 (April 08, 2013): HepatoBiliary Surgery and Nutrition Y2 - 2012 KW - N2 - Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. In this context, chronic viral hepatitis B (HBV) infection represents the most common etiology of HCC. Notably, although other common causes of HCC including chronic viral hepatitis C and chronic alcoholic liver disease are mediated by progression through cirrhosis, the pathogenesis of HCC in HBV infection does not entirely depend on this mechanism. A major proposed pathway by which HCC may arise from chronic HBV infection is the integration of HBV DNA into the host genome, resulting in oncogene activation, tumor-suppressor gene inactivation, or other predisposition to chromosomal instability (1). UR - https://hbsn.amegroups.org/article/view/1169