%0 Journal Article %T Hepatitis B virus and host factors %A Yano, Yoshihiko %A Seo, Yasushi %A Azuma, Takeshi %A Hayashi, Yoshitake %J Hepatobiliary Surgery and Nutrition %D 2012 %B 2012 %9 %! Hepatitis B virus and host factors %K %X Primary liver cancer is the third most common cause of cancer-related deaths worldwide, with a particularly high incidence in Asian countries. Hepatocellular carcinoma (HCC) accounts for 85-90% of primary liver cancers, and is responsible for approximately 660,000 deaths worldwide each year (1). Hepatitis B virus (HBV) is the most common cause of infectious liver diseases. About 400 million people suffer from chronic HBV infection worldwide, and approximately 60% of HCC cases each year are related to chronic HBV infection (2). It has been suggested that viral factors (e.g., HBV-DNA levels, genotypes, and genomic mutations), host factors (e.g., age, sex, race, and immune status), and unhealthy lifestyles might contribute to the progression of liver diseases (3). %U https://hbsn.amegroups.org/article/view/1167 %V 2 %N 2 %P 121-123 %@ 2304-389X