TY - JOUR AU - Wiggers, Jimme K. AU - te Riele, Wouter W. AU - van Dongen, Tristan H. AU - Verheij, Joanne AU - Busch, Olivier R.C. AU - van Gulik, Thomas M. PY - 2016 TI - Combined liver and extrahepatic bile duct resection for biliary invasion of colorectal metastasis: a case-cohort analysis and systematic review JF - Hepatobiliary Surgery and Nutrition; Vol 5, No 4 (August 01, 2016): Hepatobiliary Surgery and Nutrition (Special Focus on Techniques and Innovations in Liver Surgery) Y2 - 2016 KW - N2 - Background: Colorectal liver metastases (CRLMs) with biliary invasion can be treated with a combined liver and extrahepatic bile duct resection. The aim of this study was to analyze outcomes of this procedure in a case-cohort analysis and systematic review. Methods: Consecutive patients who underwent a major liver resection for CRLM between 2003 and 2013 were selected from a single center prospective database, comparing patients with and without biliary invasion. A specific and a general search strategy were used to identify relevant articles in the systematic review. Results: Ten patients (13.2%) underwent combined liver and extrahepatic bile duct resection for CLRM with biliary invasion, among 76 patients included. An R0 resection was achieved in five of ten patients (50%); one of ten patients died postoperatively. Median overall survival was 19 months among patients with biliary invasion, versus 106 months among patients without biliary invasion (P=0.12). The systematic review yielded a large variability in 5-year survival after resection of CLRM with biliary invasion, ranging between 33–80%. Conclusions: Surgical resection of CLRM with central biliary invasion is feasible, but survival in these patients tends to be lower due to a high rate of non-radical resections. UR - https://hbsn.amegroups.org/article/view/10570