Nonalcoholic fatty liver disease and type 2 diabetes: a burgeoning problem with unclear solutions

Mariana Lazo, Jeanne M. Clark


The association between chronic liver disease and diabetes has been known for long time, with reports in the literature as early as in 1952 (1). Currently, a bidirectional association between type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) has become more widely accepted, probably as a result of the common risk factors (e.g., obesity) and pathophysiology (e.g., insulin resistance) (2).