Down staging of hepatocellular carcinoma—can we push the boundaries?

Joydeep Chakraborty, Andreas Giovanni Zori, Roniel Cabrera


Liver transplantation (LT) has been the cornerstone of treatment of early hepatocellular carcinoma (HCC) within Milan criteria due to favorable long-term survival rates (1). Since the introduction of the Model for End Stage Liver Disease (MELD) exception point allocation system in 2002, patients with HCC have received priority listing. Multiple revisions have occurred to balance the increasing priority patients with HCC receive over sicker patients with non- HCC indications given the severe shortage of donor livers.