Could hepatic ablation promote development of colon cancer hepatic metastases?
Colon cancer is currently the third most common cancer and cause of cancer-related deaths in the United States. Approximately 35–55% of patients with colorectal cancer present with metastatic disease; of these, 10–20% of patients have resectable disease, with the liver being the most common site of metastasis (1). Surgical resection is considered the gold standard curative option for metastatic disease, with overall 5-yr survival of 35–55% after successful resection (1). Many patients with surgically unresectable disease, however, are candidates for microwave (MW) or radiofrequency ablation (RFA) of hepatic metastases or other liver-directed therapies. While ablation can often be performed minimally invasively or percutaneously and is generally well tolerated with effective local tumor control, it is not without limitations.