Article Abstract

Relative skeletal muscle mass and non-alcoholic fatty liver disease: from association to causation

Authors: Hee Yeon Kim, Jong Young Choi, Yong-Moon Park


The prevalence of nonalcoholic fatty liver disease (NAFLD) and its associated metabolic risk factors, including obesity and metabolic syndrome, have increased over the last decade in both developed and developing countries (1). NAFLD is considered to be the hepatic manifestation of metabolic syndrome and insulin resistance which is one of multiple hits leading to NAFLD (2). Because skeletal muscle is an important endocrine organ that responds to the insulin, loss of skeletal muscle mass decreases glucose utilization and induces insulin resistance, which in turn may contribute to the development of NAFLD (3).