Autophagy elicits a novel and prospect strategy to starve arginine-dependent tumors

Siyu Lei, Rui Fei, Liancheng Lei


With the development of the social economy and the improvement of people’s living standards, chronic non-communicable diseases have become the main cause of death, and malignant tumors are one of the leading causes of death worldwide. In recent years, the incidence of malignant tumors has shown an upward trend. It was reported that there were 17 million new cases of cancer (all cancers combined excluding non-melanoma skin cancer) and 9.6 million deaths from cancer worldwide in 2018 (1) with, lung, liver, stomach, and bowel cancers being the four most common causes of cancer death.