Hepatobiliary surgeons meet immunologists: the case of colorectal liver metastases patients

Matteo Donadon, Nina Cortese, Federica Marchesi, Matteo Cimino, Alberto Mantovani, Guido Torzilli


The burgeoning field of cancer immunology demands a change in the paradigm of cancer patient management. The understanding of the course of a given malignant disease should also include the host immune system as one of the key factors in determining the patient’s prognosis. Surgical and medical oncologists need to understand the basic and advanced applications of immunotherapies, which are rapidly evolving, and are nowadays an integral part of the armamentarium for the treatment of cancer patients. In the present work, we review the current knowledge concerning the immune landscape of colorectal cancer (CRC) patients with liver metastases, as recently discovered.