Article Abstract

One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade

Authors: Aditi Gupta, Sadna Budhu, Taha Merghoub


Tumors employ several mechanisms to evade recognition by the immune system. Among these are epigenetic changes such as loss of the antigen presenting machinery (e.g., HLA-A,B,C) that cause tumors to become invisible to the immune system.