Pure fetal hepatoblastoma in a young female
Images in Clinical Medicine

Pure fetal hepatoblastoma in a young female

Yi Cao, Chaoliu Dai

Department of Hepatobiliary and Splenic Surgery, China Medical University, Shenyang 110004, China

Correspondence to: Chaoliu Dai, PhD. Department of Hepatobiliary and Splenic Surgery, Shengjing Hospital, China Medical University, No.36 Sanhao Street, Heping District, Shenyang 110004, China. Email: daichaoliusjh@126.com.

Submitted Dec 29, 2018. Accepted for publication Dec 29, 2018.

doi: 10.21037/hbsn.2019.01.02

A 22-year-old woman noted a fist-sized mass on her upper abdomen 1 month previously. She had occasional fever. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) revealed a huge lesion in the left lobe and intrahepatic metastasis (Panels A,B). Positron emission tomography (PET)-CT showed a mixed density mass (9.5 cm × 8.0 cm) in the left liver lobe with a SUVmax =4.51 (Panel C). Serum CEA, CA 19-9 and CA15-3 were normal. Serum alpha-fetoprotein (AFP) was 53.52 ng/mL. With the clinical suspicion of a hepatic malignancy, we realize a left hepatectomy, caudate lobectomy and microwave ablation of the tumors, that shows a mixed mass with areas of hemorrhage or necrosis (Panels D,E). A H&E staining revealed the tumor cells showed thin plates or nests of small-to-medium-sized uncrowded cells resembling hepatocytes of the developing fetal liver (Panel F, 20×). Immunohistochemistry findings were as follows: CK, (+−); Vimentin (−); AFP, (+−); CD 34, (+); CgA, (−); Hepatocytes, (+); and Ki-67, (10%+). We diagnosed the tumor as a pure fetal hepatoblastoma.




Conflicts of Interest: The authors have no conflicts of interest to declare.

Informed Consent: Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images.

Cite this article as: Cao Y, Dai C. Pure fetal hepatoblastoma in a young female. Hepatobiliary Surg Nutr 2019;8(1):85-86. doi: 10.21037/hbsn.2019.01.02