Article Abstract

Gut microbiome: A key player in cancer immunotherapy

Authors: Yasuyuki Shigematsu, Kentaro Inamura


Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic approaches used to treat cancer. Immune checkpoint molecules located on tumor cells interact with receptors on cytotoxic CD8+ T cells (a type of effector T lymphocyte) and consequently lead to evasion of tumor cells from the immune system.