Article Abstract

Hydrogen sulfide and nonalcoholic fatty liver disease

Authors: Panzhi Wang, Liming Wu

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disease worldwide. The septum of NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis, the latter of which may further progress to liver cirrhosis and even more advanced stages in 20% patients (1,2). During last decade, nonalcoholic steatohepatitis has been identified as the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the United States (3). Meanwhile, NAFLD also significantly increases risk of cardiovascular diseases, type 2 diabetes, chronic kidney disease, and colorectal neoplasia.